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Generic Name: Itraconazole Capsules (Tolsura) (i tra KOE na zole)
Brand Name: Tolsura

Medically reviewed by Last updated on Jul 9, 2020.


  • Heart failure (weak heart) has happened with Tolsura (itraconazole capsules (tolsura)). If you have or have ever had heart failure, talk with your doctor. Get medical help right away if you have signs of heart failure like shortness of breath, a big weight gain, coughing up white or pink mucus, fast heartbeat, waking up at night more than normal, or swelling in the arms or legs while you take Tolsura (itraconazole capsules (tolsura)).
  • This medicine interacts with many other drugs. This may affect how well Tolsura (itraconazole capsules (tolsura)) works or cause side effects. Sometimes, these effects may be severe or deadly. Do not take Tolsura (itraconazole capsules (tolsura)) if you are taking any of these drugs: Avanafil, cisapride, dihydroergotamine, disopyramide, dofetilide, dronedarone, eplerenone, ergonovine, ergotamine, felodipine, irinotecan, isavuconazole, ivabradine, lomitapide, lovastatin, lurasidone, methadone, methylergonovine, oral midazolam, naloxegol, nisoldipine, pimozide, quinidine, ranolazine, simvastatin, ticagrelor, or triazolam. Some patients must not take Tolsura (itraconazole capsules (tolsura)) with eliglustat. There are many other drugs that must not be taken with Tolsura (itraconazole capsules (tolsura)). Check with your doctor and pharmacist to make sure that it is safe for you to take all of your other drugs (prescription or OTC, natural products, vitamins) with Tolsura (itraconazole capsules (tolsura)) or within 2 weeks after you stop taking Tolsura (itraconazole capsules (tolsura)).
  • If you have kidney or liver problems, do not take Tolsura (itraconazole capsules (tolsura)) if you are also taking fesoterodine, solifenacin, or a drug that has colchicine in it.

Uses of Tolsura:

  • It is used to treat fungal infections.

What do I need to tell my doctor BEFORE I take Tolsura?

  • If you have an allergy to itraconazole or any other part of Tolsura (itraconazole capsules (tolsura)).
  • If you are allergic to Tolsura (itraconazole capsules (tolsura)); any part of Tolsura (itraconazole capsules (tolsura)); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Tolsura (itraconazole capsules (tolsura)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Tolsura?

  • Tell all of your health care providers that you take Tolsura (itraconazole capsules (tolsura)). This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how Tolsura (itraconazole capsules (tolsura)) affects you.
  • If you have dizziness or change in eyesight, do not drive or do other tasks or actions that could be unsafe.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • Do not use longer than you have been told. A second infection may happen.
  • Talk with your doctor before you drink alcohol.
  • Hearing loss has happened with Tolsura (itraconazole capsules (tolsura)). Many times this has happened when Tolsura (itraconazole capsules (tolsura)) was taken along with quinidine. This will most often go away after Tolsura (itraconazole capsules (tolsura)) is stopped but may last for a long time in some people. Talk with your doctor.
  • If you are 65 or older, use Tolsura (itraconazole capsules (tolsura)) with care. You could have more side effects.
  • Use birth control that you can trust to prevent pregnancy while taking Tolsura (itraconazole capsules (tolsura)) and for at least 2 months after your last dose.
  • If you get pregnant while taking Tolsura (itraconazole capsules (tolsura)) or within 2 months after your last dose, call your doctor right away.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Tolsura) best taken?

Use Tolsura (itraconazole capsules (tolsura)) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Keep taking Tolsura (itraconazole capsules (tolsura)) as you have been told by your doctor or other health care provider, even if you feel well.
  • Take Tolsura (itraconazole capsules (tolsura)) at the same time of day.
  • Take Tolsura (itraconazole capsules (tolsura)) with food.
  • If you have low stomach acid or you take another drug to lower stomach acid, talk with your doctor about how to take Tolsura (itraconazole capsules (tolsura)). You may need to take Tolsura (itraconazole capsules (tolsura)) with an acidic drink like non-diet cola.
  • Swallow whole. Do not chew, break, or crush.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • A burning, numbness, or tingling feeling that is not normal.
  • Trouble passing urine.
  • Chest pain or pressure.
  • Fever or chills.
  • Change in eyesight.
  • Feeling confused.
  • Ringing in the ears, hearing loss, or any other changes in hearing.
  • Swelling.
  • Lowered interest in sex.
  • Not able to get or keep an erection.
  • Very bad and sometimes deadly liver problems have rarely happened with Tolsura (itraconazole capsules (tolsura)). Sometimes this happened within 7 days of starting this drug. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

What are some other side effects of Tolsura?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Upset stomach or throwing up.
  • Stomach pain or diarrhea.
  • Runny nose.
  • Feeling tired or weak.
  • Dizziness.
  • Not hungry.
  • Feeling sleepy.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Tolsura?

  • Store at room temperature. Do not freeze.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Tolsura (itraconazole capsules (tolsura)), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Frequently Asked Questions