Generic Name: Peginterferon Alfa-2b (Sylatron) (peg in ter FEER on AL fa too bee)
Brand Name: Sylatron
Medically reviewed on Feb 6, 2019
- Alpha interferons may cause or make diseases of the mind worse. Taking one's own life, ideas of killing yourself or murder, low mood (depression), forceful actions, hallucinations, psychoses, and relapse of drug addiction have happened during treatment and within 6 months after the last dose. Alpha interferons may also cause or make infections, blood flow problems, or autoimmune diseases worse. Some of these may be deadly. If you think you have any of these health problems, call your doctor right away. Side effects such as high or low blood pressure, a fast heartbeat, a heartbeat that does not feel normal, chest pain or pressure, trouble breathing, and heart attacks have happened while taking alpha interferons. If you have very bad signs or if signs of these health problems get worse, talk with your doctor about stopping Sylatron (peginterferon alfa-2b (sylatron)). Problems are most often fixed after you stop the drug.
Uses of Sylatron:
- It is used to treat skin cancer.
What do I need to tell my doctor BEFORE I take Sylatron?
- If you have an allergy to Sylatron (peginterferon alfa-2b (sylatron)) or any part of Sylatron (peginterferon alfa-2b (sylatron)).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have autoimmune hepatitis.
- If you have liver disease.
This is not a list of all drugs or health problems that interact with Sylatron (peginterferon alfa-2b (sylatron)).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Sylatron (peginterferon alfa-2b (sylatron)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Sylatron?
- Tell all of your health care providers that you take Sylatron (peginterferon alfa-2b (sylatron)). This includes your doctors, nurses, pharmacists, and dentists.
- Very bad and sometimes deadly pancreas problems (pancreatitis) have happened with Sylatron (peginterferon alfa-2b (sylatron)). Call your doctor right away if you have very bad stomach pain, very bad back pain, or very upset stomach or throwing up.
- Low blood cell counts have happened with Sylatron (peginterferon alfa-2b (sylatron)). If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. Call your doctor right away if you have signs of infection like fever, chills, or sore throat; any unexplained bruising or bleeding; or if you feel very tired or weak.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- Very bad and sometimes deadly liver problems have happened with Sylatron (peginterferon alfa-2b (sylatron)). Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- If you are 65 or older, use Sylatron (peginterferon alfa-2b (sylatron)) with care. You could have more side effects.
- This medicine may cause fertility problems. This may affect being able to have children. Talk with the doctor.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting Sylatron (peginterferon alfa-2b (sylatron)). Talk with your doctor.
- Use birth control that you can trust to prevent pregnancy during care. You may also need to use birth control for some time after care ends. Talk with your doctor to see if you need to use birth control after you stop Sylatron (peginterferon alfa-2b (sylatron)).
- If you get pregnant while taking Sylatron (peginterferon alfa-2b (sylatron)) or within 10 days after your last dose, call your doctor right away.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Sylatron) best taken?
Use Sylatron (peginterferon alfa-2b (sylatron)) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as a shot into the fatty part of the skin.
- If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
- Follow how to use as you have been told by the doctor or read the package insert.
- Acetaminophen may be given to lower fever and chills.
- Take at bedtime to help with flu-like signs.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
- Wash your hands before and after use.
- This medicine must be mixed with sterile water before using. The sterile water that comes with Sylatron (peginterferon alfa-2b (sylatron)) is meant for one use only. Throw away any part of the sterile water that is not used after one use.
- Do not shake.
- Do not use if the solution is cloudy, leaking, or has particles.
- Do not use if solution changes color.
- Move the site where you give the shot with each shot.
- Use right away after mixing or you may store in a refrigerator for up to 24 hours.
- Throw away any part of the opened vial not used after the shot is given.
- Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
- Tell your doctor if you take a drug that has caffeine, or you eat or drink products that have caffeine, like tea, coffee, cola, or chocolate.
- Take good care of your teeth. See a dentist often.
- If you throw up, rinse your mouth out well.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Talk with your doctor before you drink alcohol.
- High blood sugar has happened with Sylatron (peginterferon alfa-2b (sylatron)). This includes diabetes that is new or worse. Talk with the doctor.
- Check your blood sugar as you have been told by your doctor.
- High triglyceride levels have happened with Sylatron (peginterferon alfa-2b (sylatron)). Tell your doctor if you have ever had high triglyceride levels.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of thyroid problems like a change in weight without trying, feeling nervous and excitable, feeling restless, feeling very weak, hair thinning, low mood (depression), neck swelling, not able to focus, not able to handle heat or cold, period (menstrual) changes, shakiness, or sweating.
- Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Very bad dizziness or passing out.
- Change in look of teeth or gums.
- A burning, numbness, or tingling feeling that is not normal.
- This medicine may cause eye problems that may lead to loss of eyesight or blindness. Tell your doctor if you have or have ever had eye problems. Call your doctor right away if you have any changes in eyesight.
- Very bad and sometimes deadly lung problems have happened with Sylatron (peginterferon alfa-2b (sylatron)). Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
- Severe bowel problems (colitis) have happened within 12 weeks of treatment with alpha interferons like Sylatron (peginterferon alfa-2b (sylatron)). Sometimes, this could be deadly. Call your doctor right away if you have severe stomach pain, bloody diarrhea, throwing up blood, or throw up that looks like coffee grounds.
What are some other side effects of Sylatron?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Flu-like signs.
- Upset stomach or throwing up.
- Not hungry.
- Hair loss.
- Not able to sleep.
- Feeling tired or weak.
- Weight loss.
- Change in taste.
- Dry mouth.
- Irritation where the shot is given.
- Muscle or joint pain.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Sylatron?
- Store at room temperature. Do not freeze.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Sylatron (peginterferon alfa-2b (sylatron)) is refilled. If you have any questions about Sylatron (peginterferon alfa-2b (sylatron)), please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Sylatron (peginterferon alfa-2b)
- Sylatron Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: antineoplastic interferons
Other brands: PegIntron