Generic Name: c1 esterase inhibitor (recombinant) (C1 ES-ter-ase in-HIB-i-ter)
Brand Name: Ruconest
Ruconest is used for:
Treating attacks of hereditary angioedema (HAE) in teenagers and adults.
Ruconest is a C1 esterase inhibitor (human). It works by helping to control inflammation and parts of the immune system. This helps to prevent the swelling and/or painful attacks that occur with HAE.
Do NOT use Ruconest if:
- you are allergic to any ingredient in Ruconest or have had a severe allergic reaction (eg, rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness) to Ruconest, to another C1 esterase inhibitor, or to rabbits
Contact your doctor or health care provider right away if any of these apply to you.
Before using Ruconest:
Some medical conditions may interact with Ruconest. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a certain type of catheter (indwelling catheter) or device in a vein
- if you have a history of heart or blood vessel disease; stroke; thick blood; or blood or clotting problems, such as blood clots in your veins or lungs (eg, deep vein thrombosis, pulmonary embolism)
- if you have not been able to move around for some time
Some MEDICINES MAY INTERACT with Ruconest. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Estrogens (eg, certain birth control pills) or certain types of steroids (androgens, such as testosterone) because the risk of blood clots may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Ruconest may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Ruconest:
Use Ruconest as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Ruconest. Talk to your pharmacist if you have questions about this information.
- Ruconest is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Ruconest at home, a health care provider will teach you how to use it. Be sure you understand how to use Ruconest. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Ruconest if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- At the first symptoms of an attack, immediately mix Ruconest. If you are unable to mix or use Ruconest yourself, seek immediate medical attention.
- This product must be used within 8 hours after mixing. Do not freeze after mixing.
- Most of the time, 1 dose is enough to treat an attack. Sometimes, a second dose may be needed. Talk with the doctor to find out what to do after using a dose of Ruconest.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- Record the lot number from the vial of Ruconest in your treatment diary or log book with the date and time every time you use Ruconest.
- If you miss a dose of Ruconest, contact your doctor right away.
Ask your health care provider any questions you may have about how to use Ruconest.
Important safety information:
- There have been reports of blood clots (eg, in the veins or lungs) in patients using Ruconest. Contact your doctor right away if you develop symptoms of a blood clot (eg, changes in consciousness, speech, or vision; one-sided weakness or loss of muscle control; severe or persistent headache; chest pain; shortness of breath; pain, numbness, warmth, change of color, or swelling in your arms, legs, or stomach; fast heartbeat) while you are using Ruconest. Talk with your doctor for more information.
- Talk with your doctor before you travel while you are using Ruconest. Be sure to take along enough of Ruconest for your treatment while you are traveling.
- Tell your doctor or dentist that you take Ruconest before you receive any medical or dental care, emergency care, or surgery.
- PREGNANCY and BREAST-FEEDING: It is not known if Ruconest can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ruconest while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Ruconest, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Ruconest:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; headache; nausea.
Severe allergic reactions (rash; hives; itching; difficulty breathing or shortness of breath; tightness in the chest; fast heartbeat; severe dizziness or light-headedness; fainting; swelling of the mouth, face, lips, or tongue; blue gums or lips; wheezing; unusual hoarseness).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Ruconest:
Store Ruconest between 36 and 77 degrees F (2 and 25 degrees C). Do not freeze. Store in original packaging until just before use. Store away from heat, moisture, and light. Do not store in the bathroom. Do not use after the expiration date. Keep Ruconest out of the reach of children and away from pets.
- If you have any questions about Ruconest, please talk with your doctor, pharmacist, or other health care provider.
- Ruconest is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Ruconest or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Ruconest. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Ruconest. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Ruconest.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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