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Polivy

Generic Name: Polatuzumab Vedotin (POL a TOOZ ue mab ve DOE tin)
Brand Name: Polivy

Medically reviewed by Drugs.com. Last updated on Jul 29, 2019.

Uses of Polivy:

  • It is used to treat a type of lymphoma.

What do I need to tell my doctor BEFORE I take Polivy?

  • If you have an allergy to Polivy (polatuzumab vedotin) or any part of Polivy (polatuzumab vedotin).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have liver disease.
  • If you are breast-feeding. Do not breast-feed while you take Polivy (polatuzumab vedotin) or for 2 months after your last dose.

This is not a list of all drugs or health problems that interact with Polivy (polatuzumab vedotin).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Polivy (polatuzumab vedotin) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Polivy?

  • Tell all of your health care providers that you take Polivy (polatuzumab vedotin). This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • Infusion reactions have happened with Polivy (polatuzumab vedotin). These have happened on the same day as the infusion. Tell your doctor if you have any bad effects during or after the infusion.
  • Patients with cancer who take Polivy (polatuzumab vedotin) may be at a greater risk of getting a severe health problem called tumor lysis syndrome (TLS).This may lead to death. Call your doctor right away if you have a fast or abnormal heartbeat; any passing out; trouble passing urine; muscle weakness or cramps; upset stomach, throwing up, diarrhea, or not able to eat; or feel sluggish.
  • If you are 65 or older, use Polivy (polatuzumab vedotin) with care. You could have more side effects.
  • This medicine may affect being able to father a child. Talk with the doctor.
  • Men with a partner who may get pregnant must use birth control while taking Polivy (polatuzumab vedotin) and for some time after the last dose. Ask your doctor how long to use birth control. If your partner gets pregnant, call the doctor right away.
  • This medicine may cause harm to an unborn baby. A pregnancy test will be done before you start Polivy (polatuzumab vedotin) to show that you are NOT pregnant.
  • Women must use birth control while taking Polivy (polatuzumab vedotin) and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.

How is this medicine (Polivy) best taken?

Use Polivy (polatuzumab vedotin) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.
  • Other drugs will be given with Polivy (polatuzumab vedotin) to help avoid side effects.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
  • Feeling very tired or weak.
  • Flushing.
  • Shortness of breath.
  • Very bad dizziness or passing out.
  • A burning, numbness, or tingling feeling that is new or worse.
  • Muscle weakness.
  • Trouble walking.
  • A very bad brain problem called progressive multifocal leukoencephalopathy (PML) has happened with Polivy (polatuzumab vedotin). It may cause disability or can be deadly. Tell your doctor right away if you have signs like confusion, memory problems, low mood (depression), change in the way you act, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.

What are some other side effects of Polivy?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling tired or weak.
  • Diarrhea.
  • Throwing up.
  • Not hungry.
  • Dizziness.
  • Signs of a common cold.
  • Weight loss.
  • Joint pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Polivy?

  • If you need to store Polivy (polatuzumab vedotin) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Polivy (polatuzumab vedotin), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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