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Phenylephrine and Ketorolac

Generic name: Phenylephrine and Ketorolac (fen il EF rin & KEE toe role ak)
Brand name: Omidria
Drug class: Ophthalmic surgical agents

Medically reviewed by Last updated on Dec 7, 2020.

Uses of Phenylephrine and Ketorolac:

  • It is used during eye surgery.
  • It is used to lower eye pain after eye surgery.

What do I need to tell my doctor BEFORE I take Phenylephrine and Ketorolac?

  • If you are allergic to phenylephrine and ketorolac; any part of phenylephrine and ketorolac; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you are pregnant or may be pregnant. Do not take phenylephrine and ketorolac if you are in the third trimester of pregnancy. You may also need to avoid phenylephrine and ketorolac at other times during pregnancy. Talk with your doctor to see when you need to avoid taking phenylephrine and ketorolac during pregnancy.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take phenylephrine and ketorolac with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Phenylephrine and Ketorolac?

  • Tell all of your health care providers that you take phenylephrine and ketorolac. This includes your doctors, nurses, pharmacists, and dentists.
  • Bright lights may bother you. Wear sunglasses.
  • High blood pressure has happened with phenylephrine and ketorolac. Have your blood pressure checked as you have been told by your doctor.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Phenylephrine and Ketorolac) best taken?

Use phenylephrine and ketorolac as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • For the eye only.
  • Your doctor will give phenylephrine and ketorolac.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Very bad eye irritation.

What are some other side effects of Phenylephrine and Ketorolac?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Phenylephrine and Ketorolac?

  • If you need to store phenylephrine and ketorolac at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about phenylephrine and ketorolac, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.