Phenylephrine and ketorolac (Ophthalmic)

Generic name: phenylephrine and ketorolac [ kee-toe-ROLE-ak, fen-il-EF-rin ]
Brand name: Omidria
Drug class: Ophthalmic surgical agents

Medically reviewed by Drugs.com. Last updated on Jun 9, 2024.

Uses for phenylephrine and ketorolac

Ketorolac and phenylephrine ophthalmic solution is combined with an eye irrigation solution used during cataract surgery or intraocular lens replacement. This is to maintain pupil size by preventing intraoperative miosis (pupil constriction) and to reduce pain after eye surgery.

This medicine is to be given only by or under the direct supervision of your eye doctor (ophthalmologist).

Before using phenylephrine and ketorolac

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ketorolac and phenylephrine ophthalmic solution in the pediatric population.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ketorolac and phenylephrine ophthalmic solution in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Aceclofenac
Acemetacin
Amtolmetin Guacil
Aspirin
Bromfenac
Bufexamac
Celecoxib
Choline Salicylate
Clonixin
Clorgyline
Dexibuprofen
Dexketoprofen
Diclofenac
Diflunisal
Dipyrone
Droxicam
Etodolac
Etofenamate
Etoricoxib
Felbinac
Fenoprofen
Fepradinol
Feprazone
Floctafenine
Flufenamic Acid
Flurbiprofen
Ibuprofen
Indomethacin
Iproniazid
Isocarboxazid
Ketoprofen
Linezolid
Lornoxicam
Loxoprofen
Lumiracoxib
Meclofenamate
Mefenamic Acid
Meloxicam
Morniflumate
Nabumetone
Naproxen
Nepafenac
Nialamide
Niflumic Acid
Nimesulide
Nimesulide Beta Cyclodextrin
Oxaprozin
Oxyphenbutazone
Parecoxib
Pentoxifylline
Phenelzine
Phenylbutazone
Piketoprofen
Piroxicam
Procarbazine
Proglumetacin
Propyphenazone
Proquazone
Rasagiline
Rofecoxib
Salicylic Acid
Salsalate
Selegiline
Sodium Salicylate
Sulfasalazine
Sulindac
Tenoxicam
Tiaprofenic Acid
Tolfenamic Acid
Tolmetin
Tranylcypromine
Valdecoxib

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abciximab
Acenocoumarol
Anagrelide
Apixaban
Ardeparin
Argatroban
Bemiparin
Betamethasone
Bivalirudin
Budesonide
Cangrelor
Certoparin
Cilostazol
Citalopram
Clopidogrel
Cortisone
Dabigatran Etexilate
Dalteparin
Danaparoid
Deflazacort
Desirudin
Desvenlafaxine
Dexamethasone
Dipyridamole
Duloxetine
Edoxaban
Emtricitabine
Enoxaparin
Epoprostenol
Eptifibatide
Escitalopram
Feverfew
Fluocortolone
Fluoxetine
Fluvoxamine
Fondaparinux
Furazolidone
Ginkgo
Heparin
Hydrocortisone
Iloprost
Lepirudin
Levomilnacipran
Meadowsweet
Melphalan
Methotrexate
Methylprednisolone
Midodrine
Milnacipran
Nadroparin
Nefazodone
Paramethasone
Pargyline
Parnaparin
Paroxetine
Phenindione
Phenprocoumon
Prasugrel
Prednisolone
Prednisone
Protein C
Reviparin
Rivaroxaban
Selexipag
Sertraline
Sibutramine
Sulfinpyrazone
Sulodexide
Tenofovir Alafenamide
Ticagrelor
Ticlopidine
Tinzaparin
Tirofiban
Treprostinil
Venlafaxine
Vilazodone
Vorapaxar
Vortioxetine
Warfarin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Guanethidine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Proper use of phenylephrine and ketorolac

Your eye doctor will give you this medicine in a hospital. It is injected into your eyes.

Precautions while using phenylephrine and ketorolac

Your eye doctor will check your eyes closely while you are receiving this medicine to make sure it is working properly and is not causing unwanted effects.

This medicine may cause an increase in your blood pressure. Tell your doctor right away if you have blurred vision, dizziness, nervousness, headache, pounding in the ears, or slow or fast heartbeat.

Tell your doctor if you experience a sensitivity to light while receiving this medicine.

Side Effects of phenylephrine and ketorolac

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Decreased vision or other changes in vision
loss of vision

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Fainting
fast, pounding, or irregular heartbeat or pulse
fear or nervousness
headache
nausea
vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common