Generic Name: Mitotane (MYE toe tane)
Brand Name: Lysodren
Medically reviewed by Drugs.com. Last updated on Mar 17, 2020.
- This medicine lowers how much natural steroid your body makes. Tell your doctor if you have fever, infection, surgery, or injury. Your body's normal response to these stresses may be affected. You may need extra doses of steroid.
Uses of Mitotane:
- It is used to treat cancer of the adrenal gland.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Mitotane?
- If you are allergic to mitotane; any part of mitotane; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you are breast-feeding. Do not breast-feed while you take mitotane. You will also need to avoid breast-feeding after you stop mitotane until there is no more of mitotane in your body. Talk with your doctor to see how long you need to avoid breast-feeding after you stop this drug.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take mitotane with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Mitotane?
- Tell all of your health care providers that you take mitotane. This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may cause high cholesterol and triglyceride levels. Talk with the doctor.
- This medicine may affect growth in children and teens in some cases. They may need regular growth checks. Talk with the doctor.
- This medicine may cause harm to the unborn baby or loss of the unborn baby if you take it while you are pregnant.
- Use birth control that you can trust to prevent pregnancy while you take mitotane. You will also need to use it after you stop mitotane until there is no more of mitotane in your body. Talk with your doctor to see how long you need to use birth control after you stop mitotane.
- If you get pregnant while taking mitotane or within several months after the last dose, call your doctor right away.
How is this medicine (Mitotane) best taken?
Use mitotane as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- You will need to take special care when handling mitotane. Check with the doctor or pharmacist to see how to handle mitotane.
- Keep taking mitotane as you have been told by your doctor or other health care provider, even if you feel well.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of a weak adrenal gland like a very bad upset stomach or throwing up, very bad dizziness or passing out, muscle weakness, feeling very tired, mood changes, not hungry, or weight loss.
- Signs of low thyroid levels like constipation; not able to handle cold; memory problems; mood changes; or a burning, numbness, or tingling feeling that is not normal.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Change in eyesight.
- Feeling confused.
- Low mood (depression).
- Change in balance.
- Change in speech.
- Enlarged breasts.
- Ovarian cysts have happened with mitotane in women who have not been through menopause. Sometimes, very bad effects like ruptured cysts have happened. Call your doctor right away if you have vaginal bleeding that is not normal or pelvic pain.
- Low white blood cell counts have happened with mitotane. This may lead to a higher chance of getting an infection. Call your doctor right away if you have signs of infection like fever, chills, or sore throat.
What are some other side effects of Mitotane?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling dizzy, sleepy, tired, or weak.
- Diarrhea, throwing up, upset stomach, and feeling less hungry are common with mitotane. If these happen, talk with your doctor about ways to lower these side effects. Call your doctor right away if any of these effects bother you, do not get better, or get very bad.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Mitotane?
- Store at room temperature in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about mitotane, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about mitotane
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Compare Alternatives
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- Drug class: miscellaneous antineoplastics
Other brands: Lysodren