Generic Name: minocycline (MIN-oh-SYE-kleen)
Brand Name: Arestin
Minocycline microspheres are used for:
Preventing or treating certain gum problems that may occur after certain dental procedures to treat inflammatory gum disease (periodontitis). It may also be used as part of a gum care maintenance program in some patients who have periodontitis. It may also be used for other conditions as determined by your doctor.
Minocycline microspheres are a tetracycline antibiotic. It works by slowing the growth of certain bacteria and allowing the body's immune system to kill them.
Do NOT use minocycline microspheres if:
- you are allergic to any ingredient in minocycline microspheres or to other tetracyclines (eg, doxycycline)
- you are taking acitretin, isotretinoin, a live oral typhoid vaccine, methoxyflurane, or a penicillin
Contact your doctor or health care provider right away if any of these apply to you.
Before using minocycline microspheres:
Some medical conditions may interact with minocycline microspheres. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of oral fungal infections
- if you have a weakened immune system, an autoimmune disorder (eg, lupus), diabetes, or HIV, or if you are receiving chemotherapy or radiation treatment
Some MEDICINES MAY INTERACT with minocycline microspheres. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Aluminum salts (eg, carbonate) or urinary alkalinizers (eg, sodium bicarbonate) because they may decrease minocycline microspheres's effectiveness
- Acitretin, anticoagulants (eg, warfarin), digoxin, ergot alkaloids and derivatives (eg, ergotamine), insulin, isotretinoin, methotrexate, methoxyflurane, or theophyllines because the risk of their side effects may be increased by minocycline microspheres
- Live oral typhoid vaccine, oral contraceptives (birth control pills), or penicillins because their effectiveness may be decreased by minocycline microspheres
This may not be a complete list of all interactions that may occur. Ask your health care provider if minocycline microspheres may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use minocycline microspheres:
Use minocycline microspheres as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Minocycline microspheres are usually given at your dentist's office or clinic.
- If you miss a dose of minocycline microspheres, contact your doctor right away. You may need to reschedule your appointment.
Ask your health care provider any questions you may have about how to use minocycline microspheres.
Important safety information:
- Long-term or repeated use of minocycline microspheres may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- Minocycline microspheres may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to minocycline microspheres. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Minocycline microspheres only works against bacteria; it does not treat viral infections (eg, the common cold).
- Proper dental care is important while you are taking minocycline microspheres. Do not brush your teeth or touch the treated area for at least 12 hours after treatment, or as directed by your dentist. Do not use other dental cleaning devices for 10 days after treatment with minocycline microspheres, or as directed by your dentist.
- Avoid chewing hard, crunchy, or sticky food (eg, carrots, taffy, gum) for at least 1 week after treatment.
- Minocycline microspheres may cause mild irritation or increased sensitivity of your gums during the first week after treatment. Tell your doctor right away if pain, swelling, or other problems occur.
- If severe diarrhea or stomach pain or cramping develop during treatment or within several months after treatment with minocycline microspheres, check with your doctor or pharmacist right away. Do not treat it with nonprescription (over-the-counter) medicines.
- Tell your doctor or dentist that you take minocycline microspheres before you receive any medical or dental care, emergency care, or surgery.
- Be sure to use minocycline microspheres for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- Hormonal birth control (eg, birth control pills) may not work as well while you are using minocycline microspheres. To prevent pregnancy, use an extra form of birth control (eg, condoms).
- Use minocycline microspheres with extreme caution in CHILDREN younger than 10 years old who have diarrhea or an infection of the stomach or bowel.
- Minocycline microspheres should not be used in CHILDREN younger than 8 years old; safety and effectiveness in these children have not been confirmed. Using minocycline microspheres in CHILDREN younger than 8 years old or in women during the last half of pregnancy may cause permanent changes in the tooth coloring and tooth enamel problems in the child.
- PREGNANCY and BREAST-FEEDING: Minocycline microspheres has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using minocycline microspheres while you are pregnant. Minocycline microspheres are found in breast milk. Do not breast-feed while taking minocycline microspheres.
Possible side effects of minocycline microspheres:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Flu-like symptoms; headache; stomach upset.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding or discharge from the gums; fever; joint pain; muscle pain or weakness; painful sores in the mouth; red, swollen, or blistered skin; severe diarrhea; severe or persistent headache; stomach pain or cramps; unusual tiredness or weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of minocycline microspheres:
Store minocycline microspheres between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep minocycline microspheres out of the reach of children and away from pets.
- If you have any questions about minocycline microspheres, please talk with your doctor, pharmacist, or other health care provider.
- Minocycline microspheres are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take minocycline microspheres or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about minocycline microspheres. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to minocycline microspheres. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using minocycline microspheres.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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