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What happens when you mix tramadol with muscle relaxer?

8 Answers

Vickie Allen 10 Oct 2019

You can absolutely have a serious drug reaction by mixing the two especially if you are taking any antidepressants, benzos, (like valium, or Xanax), alcohol, herb's, and any psychotropic drugs, etc. I was prescribed both tramadol, and flexeril to be taken together, needless to say I ended up in the ER with seizures, and I have never had seizures in my lifetime.. They almost took my life. BE VERY CAUTION!!! (NOTE!!) ALWAYS RESEARCH MEDICATION..

Votes: +0
Alaskarange 27 Aug 2018

I take Tramadol for a severe case of RLS. I was also having back problems at that time, and decided to take a flexeril. I ended up in the hospital, and placed in a medically induced coma from serotonin syndrome. Definitely not a good idea to mix the two drugs.

Votes: +0
blue moon baby 17 July 2015

Not sure for everyone as each person can react differently. I only speak from personal experience. I have taken both together for almost 20 years but just as needed. The biggest issue with many ppl is they think they have to take them every day 3 times a day, pain or not. I only take them when I really hurt. I have trained myself to sleep through the painr but tramadol and a muscle relaxer be a God send. I stick with my rheumatologist and avoid pain specialists.One caused me to go through out patient detox.

Votes: +0
Delila 5 Oct 2013

Hi, different types of muscle relaxants show different results. For example Tramadol taken with Robaxin come up with a moderate interaction risk:,1588-964
Whereas Tramadol taken with Quinine, show no interaction risks:,2221-0
And as Masso has already commented, Tramadol taken with Flexeril show a major interaction risk:,758-386 It really depends on the individual medication, not the class - muscle relaxants

Votes: +2
masso 5 Oct 2013

Great answer Delila.

Delila 5 Oct 2013

Thank you : )

masso 5 Oct 2013

You are welcome.-Have a good weekend!

MacIntosh12 5 Oct 2013

Hi Delila and masso,
D, thank you for this answer and masso, you too. I'd NO idea that flexeril and tramadol could have such a big interaction!

masso 5 Oct 2013

Gracias Lara!!! OLO

MacIntosh12 5 Oct 2013

De nada, A... OLO yourself!! : )

Sandraway80 20 April 2017

Thank you very much for this comment! Great info.

Inactive 4 Oct 2013

Hello julieredose. Sedation, fatigue, cognitive impairment, motor skills etc. Regards pledge

Votes: +1
DzooBaby 4 Oct 2013

People use muscle relaxants and pain meds together every day. Taking them together helps each one work better (potentiates) but it can also increase side effects like sedation, drowsiness, CNS (Central Nervous System) depression, etc. They should be used together judiciously and never use both plus alcohol.

Votes: +3
kaismama 4 Oct 2013

Not allot. I take tramadol and tizanidine every day.

Votes: +2
MacIntosh12 5 Oct 2013

Hi km and DZ, I've also taken them together... many times! Had NO idea they interacted so badly (for folks who are not tolerant of both meds.)

masso 5 Oct 2013

Hello to you and evey Lady present.
Mac,i Hope you are well in every aspect of you life... Lara...

masso 4 Oct 2013

It would not be a good idea.

Flexeril (cyclobenzaprine) is a muscle relaxant and here is the interaction result:

Interactions between your selected drugs

cyclobenzaprine ↔ tramadol
Applies to: Flexeril (cyclobenzaprine), tramadol
Talk to your doctor before using traMADol together with cyclobenzaprine. TraMADol may cause seizures, and taking it with other medications that can also cause seizures such as cyclobenzaprine may increase that risk. The interaction may be more likely if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. You should avoid or limit the use of alcohol while being treated with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you. Call your doctor immediately if you experience seizures while using the medications.


It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Other drugs that your selected drugs interact with

tramadol interacts with more than 300 other drugs.
Flexeril (cyclobenzaprine) interacts with more than 300 other drugs.

Interactions between your selected drugs and food

No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.

Votes: +2 free discount card

Related topics

tramadol, muscle, muscle relaxer

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