I have previously been on Methotrexate (with relative success but terrible nausea and hair loss), leflunomide (with no success), and Humira (with limited success but hair loss and anxiety over the injection recoil). I'm wondering how Xeljanz has compared with other drugs, specifically Methotrexate, in terms of side effects and success with RA symptoms. Was Methotrexate worse for you? Does relief with Xeljanz outweigh the side effects or the potential to return to poisonous Methotrexate??