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When is the best time to take effexor xr? Morning noon or night?

10 Answers

Nitro061 23 Oct 2018

XR means extended release so it will work all day. Taking at night would serve no purpose unless you are a shift worker.

Votes: +0
Shellabbyz 25 Oct 2018

I think it is for 24 hours... I definitely notice when mine is due to take at the end of the day.

Octopink Robson 21 Oct 2018

I was switched to venlafaxine 75mg slow release 4mths ago. I was talking them when I wake up around noon daily. I spent all day with nausea and lost weight quickly. I have now started taking them at night around midnight. Its been a week and there is only slight nausea but my appetite has increased although I am lethargic and dosey during the remainder of the day. I need at least 12hours sleep on this medication and wish I could go back onto sertraline again, but this caused bowel bleeds. I have been on higher doses of venlafaxine but developed serotonin syndrome on 175mg, and also anorexia - twice previously on venlafaxine. I am going to ask to try something else this week. I feel that this drug will not get any better for me. It does keep my moods more stable but my quality of life is greatly affected by the side effects. Namaste

Votes: +0
Shellabbyz 25 Oct 2018

I had the same reaction when I started but once my body was used to it (about a month to 6 weeks in) it has disappeared. No more grogginess and I'm able to hold a conversation. This medication has changed my life.

Shellabbyz 25 Oct 2018

I also take mine before bed. The nausea was worse when I took it in the morning

Adorable1 31 Aug 2016


Votes: +0
Inactive 31 Aug 2016

How adorable

ColRanger 30 March 2011

Am re-starting Meds after years off. Initial dose 37.5 1 wk then 1 cap twice daily; so am starting w/evening meal. Would let you know how this works, but only ONE Post Allowed. [fyu was at 300+Mg when had to stop]

Votes: +1
Birdhappy 23 July 2010

Amanda1525, I took Effexor xr in the morning for years as that was how it was prescribed. But, I always felt so tired out and sleepy. Finally, about six months ago I switched it to bedtime and I now I get a good night sleep which I was never got before, because I have insommia, without the feeling of being so dragged out & tired all day long. Talk to my Dr and she said it was ok I long as I took it. So what I'm saying is experiment & find out what works for you. Everyone is different.

Votes: +3
till33 14 April 2010

when i took this medication i started oput taking it in the am but it really made me drowsy so in my opinion its better too take effexor a couple hours before bedtime.but everyone is different so what ever works best for you ..good luck

Votes: +2
psych major 13 April 2010

I took this for many years and tried both but the best was at night as it helps you relax, you get tired on the drug and arent supposed to operate heavy machinery until your body gets used to it so best at bedtime. Youll get a wondrful nite sleep and hopefully dont wake up dizzy from it.

Votes: +2
ellinam 24 May 2012

its a week i am taking effexor xr 300mg at 4 pm and next morning iam getting up really dizzy.but when i am taking it in the morning i feel tired and sleepy all day. what can i do ?

leadcow 16 Feb 2018

I have been taking 37.5 mg at bedtime for 4 months and it works well with no side effects. Helps me sleep and handle stress the next day. My husband notices if I miss a dose My motto is if a little is good, less will be better.

vanessab2 19 March 2018

300mg is a very high dose. Did your Dr. prescribe this as your first Effexor Rx? Mine always tries the lower dose first so I'm not taking more than needed. Night works good for me as it helps me sleep. I'm too tired during the day if I take it in the morning.

bjuhlman 13 April 2010

I always took in the evening, 2-3 hours before bedtime, with food. I had trouble sleeping and this worked for me.hope this helps.

Votes: +4
Erod2009 28 June 2017

Really? & you're able to sleep through the night?

Bsteinbrueck 13 April 2010

In the morning with food works best for me :)

Votes: +0
kellyandtodd 12 April 2010

those types of meds are best taking in the morning but if they have side effects that bother you take them at night.hope this helps

Votes: +2 free discount card

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effexor xr, depression, anxiety and stress

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