I used to be on oxycodone 10/325 8 times per day. I have a new Dr. and he switched me to 15mg IMM rel tabs oxycodone twice a day. I just started yesterday by taking half at a time. I didn't really notice any relief. Which med is more potent? The 15 mg has no acetaminophen in and the others have 325 mgs of acetaminophen. I'm confused!
What is stronger oxycodone 15mg or 10/325?
Question posted by cheeks24 on 4 March 2011
Last updated on 17 February 2022
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15 Answers
GypsyRodman
15 March 2018
I am trying the 15mg right now for first time. I have been on Percocet 10/325 for years. “Along time “ now dr’s want too just take me off everything. Even The Valium 10mg for anxiety I have been on for over 10 years. They told me
“You may cease” (die) I can’t believe a dr would say these things too a person with anxiety!!! Well hope you feel better. I just wanted too vent.
Myryan
20 Sep 2017
I have been on oxycodone 10 325 for 6 years dr just gave me 15 mg oxycodone I have had a bad headache I feel the 10 worked better but I had to take more
lrnngray
1 May 2017
Does oxycodone 10/325 oxycodone 15 do they have the same ingredients
Outcasted2004
5 March 2017
Oxycodone and Oxycotin do indeed attack different pain receptors in different ways. Back to the OP ... the 10/325 mg oxycodone/acetaminophen 8 times a day is stronger than the 15mg IMM Rel tabs oxycodone twice a day. As stated above, you have went from 80mg down to 30mgs even though it's now extended time release. Has your doctor discussed the possibility of a intrathecal pain pump? They work wonders and prevents other organ damage due to the micro amounts needed to numb the nerves in the spinal cord. I suffer from failed back surgery syndrome, Complex regional pain syndrome (CRPS) and severe neuropathy. My pain pump has controlled 80% of my pain and got me back to living a much better life! Good luck from another that's been there and knows what you are going through!
kstrader21
12 Dec 2016
Kodia, don't assume that others are naive, when you also gave incorrect information. OxyContin is a brand, whereas oxycodone is a chemical compound. Just like Tylenol is a drug brand that contains acetaminophen. OxyContin is pure oxycodone with a built in time release mechanism. Roxicodone, on the other hand, is pure oxycodone without a time release mechanism. For example, blue 30mg Roxicodone pills are immediate release oxycodone unalterated by acetaminophen. Therefore, you are incorrect that Percocet is the only formulation of oxycodone that is immediate release because Roxicodone is technically immediate release pure oxycodone and the person who posed the question was referring to IR tablets (if I'm not mistaken?).
Kodiaklake
15 Sep 2016
Wow some people have no clue what they are talking about on here. First of all he said Oxycodone which is not the same as OxyContin. He is taking 15mg of Oxycodone which is immediate release.
I have been on this stuff for a long time and I have a background in pharmacology. But anyway you need a higher dose.. Your use to taking 80mg a day. You should be taking OxyContin 40mg twice a day. Or better yet get away from the pills and go to a Fentynal patch. Works much better and you only have to change it every 48-72hrs.
England6England 3
4 May 2017
I take 5mg. OXYCODONE 325 ACTE. Four times a day. I want to know if I there is Oxycodone that does not include the ACTE. just the Oxycodone so I don't damage my liver?
Lildarln
11 March 2016
we have the same concern. i have been on the percocet 10/ 325 for years but was changed to 15 mg. of IR oxycodone. It makes me sugglish but doesent help my pain as much. im thinking about calling my doctor and take these back and get my other script im use too
Myryan
20 Sep 2017
I feel the same tired n a headache I wonder why but I'm scared long term to keep on 10 325 due to Tylenol I spoke to another dr and 2 nurses that said to try to keep it going cause long term it's safer
Myryan
22 Sep 2017
I feel the same it's awful I went back to dr and got right back on 10 325
sheila1972
17 Feb 2022
welol to be blatantly honest it does not take a rocket scientist to realize that a 5 mg jump without the 325 mg of acetaminophen will keep the nose from running and the headaches and dizzy spells at bay .my answer is just take 2 aspirin until you taper yourself off
ex My mother will have a headache if she doesn't have her 2 cups of tea in the morning .and that will ruin her whole day ,we are content when routine isn't interfered with
my advice is to take two acetaminophen everyday until you can gradually break it down.as long as you do not have liver or other factors that would interfere
but its always important to get a doctors second opinion
Sansom
19 Feb 2016
Obviously the 15mg poll is more potent than the 10mg. But he went from 80 mgs. a day to 30... and that's a bummer
trooper1234
14 Feb 2016
I am not really sure since I take he 15 as a jump start to 30 time released
abbyinokc
5 Aug 2015
The Oxycodone 10/325 is stronger than the 15 m.g. Oxycodone because the acetaminophen, which is the "325," actually potentiates the action of the Oxycodone, making it stronger.
billyb1966
17 Sep 2016
Tylenol does not potentiates the oxycodone. Its simply there to keep pt from hopefully not take more then directed.
A basic filler.
Besides. 15mg might have 10mg of actual medication
plh5195
18 Feb 2015
Of course the 15mg is stronger, people think because because of the acetaminophen it is stronger u should not take the 10/325 no longer than eight years due to liver damage...
yookerdon
11 Oct 2015
It's really odd that you are taking 10 MG of oxygen 8 times a day
abbyinokc
31 Dec 2015
Yookerdon - not oxygen. Oxycodone.
gbryant78
29 Nov 2014
15 mg oxycodone is stronger with out the danger of long term liver problems kidney
Myryan
20 Sep 2017
Did u get any headaches switching over I switched from 10 325 after 6 yrs to 15 mg n feel like it helped but got sinus like headache all day
catspaw1955
30 Sep 2012
the 15mg oxycodone is stronger. catspaw1955
Tlmusick
25 March 2012
First of all, the 15mg IR is stronger than the 10/325. They are the same chemical, just one has Tylenol. The brand name for the 15mg is Oxycotin or Roxycotin. Though if you were taking 8 of the 10mg a day & now taking 2 of the 15mg a day. You've gone from taking 80mg a day to 30mg a day. Doctors try to do this sometimes hoping the patient won't notice. Hope this helps.
bcrd5000
6 April 2014
Despite the comments that Oxycontin (TR) is stronger than Percocet 10/325, I have taken both for several years and Percocet is much stronger because it is designed to be a break-through pain relieve drug while Oxycontin was converted to time-release several years ago because of severe abuse.
If you are looking for immediate relieve from pain, Percocet is the superior drug since relieve comes within 30 minutes or less.
gbryant78
29 Nov 2014
What OxyContin have to do with the question
DancnDar
14 Feb 2016
Not all oxycodone is time release. I take a 15mg oxycodone that is immediate release.
Sansom
19 Feb 2016
Yeah, oxycontin wasn't even in the question. But since u brought it up oxycontin has always been time released... it's "oxy", for oxycodone... and "contin" is short for continuous.
plh5195
1 May 2017
Taking 5 of the 15s so that's 80 mg don't think I would get over 8 of the 10/325
smiles15
22 Nov 2011
The 15mg with no acetaminophen is definitely stronger than the 10mg with 325 acetaminophen. Acetaminophen is whats in tylenol.
Related topics
Further information
- Oxycodone uses and safety info
- Oxycodone prescribing info & package insert (for Health Professionals)
- Side effects of Oxycodone (detailed)
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