Hi all, have been on Zoloft 50mg for about 4 months for depression and anxiety - was doing ok (I know, it's a small dose) yet three weeks ago I had a major relapse, including goodbye libido. Pdoc has now added 150mg of Wellbutrin to the mix; he feels this is better than upping the Zoloft and should return the libido. My question is - will I have any ramp-up side effects with Wellbutrin, similar to those of first starting out on a med, and, has this mix of Zoloft and Wellbutrin worked for others out there ... I appreciate your opinion as I continue my journey to just experience a genuine smile from within, after numerous years of suffering. Many thanks in advance for your responses.