I have been taking Wellbutrin SR 150 mg twice a day for a few years now. I have been tolerating that dose fine. My doctor feels I need to increase to 3 x a day for a total of 400 mg a day now due to worsening depression and anxiety. I am scared of taking this dose! I have read all the hype about Wellbutrin and seizure risk at higher dose - I don't want that to happen, but my doctor said she had never seen anyone herself that has ever had a seizure due to Wellbutrin. Anyone out there have any advice? Thanks!
Wellbutrin SR - Help - Anyone Taking 400 mg of Wellbutrin (buproprion) SR???
Question posted by bethann31 on 26 April 2016
Last updated on 4 February 2025 by MizuzFritz
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21 Answers
MizuzFritz
5 Feb 2025
Don't do it. Get a different antidepressant. Bupropion is contraindicated for anyone with anxiety. It also lowers seizure threshold more than other antidepressants and especially when combined with other antidepressants. Happened to me, and I barely survived to tell the tale.
WildcatVet
4 Feb 2025
Hi, bethann!
Go for it. The risk of a seizure is far outweighed by the potential benefit to you. It has been reported but very, very rarely.
Personally, I took 450mg/day for years and now am taking Aplenzin which is a formulation of bupropion that's the equivalent of 522mg. I've never had any problems with it.
Of course, everyone responds differently but I do think you should give it a try.
Regards, Wildcat
Sdelou
4 Feb 2025
I have been taking 3 x 150 for several years now. I have been diagnosed with major depressive disorder. I haven’t had any problems with seizures. I hope this helps you.
Iron_Sandman
11 Oct 2018
I have been taking 400 mg of bupropion for years. I take it in 2 doses. 200 mg in the morning and 200 mg in the afternoon. I have not had any serious negative side effects from it (possibly a dryer mouth). My understanding is that the seizure risk is greater for those who have or have had seizures or for some reason (genetics, etc.) have a predisposition toward seizures. Use of alcohol with the med can increase chance of seizures. I would discuss your health history with your doctor and then make an informed decision from there. It has been a helpful medication for me.
LittleOne44
3 May 2018
400 caused me more anxiety and anger issues. I ended up on 15 mg of trintellix & 200SR bupropion & it works well for me.
andyandkrystal1991
25 Feb 2018
Yes my name Andy my doctor put me on 400mg of Wellbutrin at the jump, I didn't go from the small dose to the highest dose. I never started to have seizures until I first got on it, and all the side effects I had are accurate. I am getting off of this medicine because I think it's time to try something new
JohnFridge
20 Feb 2018
After about 14 years of this and that, I have become to know myself as far as what I believe will help, but having a Dr. that will listen is key.
I started back with 150 xr once I was about 2 weeks from my apointment I raised myself to 300. I could tell it was working in some way. Probably one of the best things is that it can help be a stimulant and help with attention.
After my apointment we agreed I would have access to 3 x 150 aka 450 per day. I feel it will be best as 300 early and 150 by 2 at the latest. At night I take Depakote 500 x 2 because I was having some serious issues with lights, movies, and passing out (Some say they observed light seizures and thats big in my family.)
Finally Alprazolam 2mg as needed which may be 1 for sleep or up to 4 (This only happens in severe situations.)
Again I feel the MOST IMPORTANT part of treatment is that you, the patient, has to have just as much say as your doctor. However, you have to educate yourself about what you wish to discuss. If your goal is to get something you do not really need, then you are seriously messing up all the progress you have made. Just be honest... If you have a good Doctor, and good repor, then Always tell your doctor your concerns.
Back to Wellbutrin/Bupropion it's good for me, hopefully for you, but take what you need it could be up to 450 at once, or slightly spaced dosing.
Solipsist1
8 Aug 2017
I wouldn't worry. I take 450mg and I also take 72 mg of concerta so no problems for me
chuck1957
8 July 2017
bethann31; You have a lot of good advice here. Your doctor is correct part you have problems with meds as you said they found one you have done well on in the past. S o this is why an increase still in the normal dose range is normal. And yes I have taken it the Sr tid myself.
What I think you are feeling right now is normal when starting a medication or increasing the dose of a medication you can get the effects your saying for a brief time 5 to 10 days or so then they should go away. And hopefully you well feel better in a while remember it has to build up in your system be for the depression lifts and all of us is different in that area I would give it 4 to 6 weeks and take it at the same time and you can take this with a light snack and see if that helps with the stomach ache feeling if not check back with your doctor Best of luck to you
Ecatfish
8 July 2017
I am taking 450mg Wellbutrin XL generic. I've been taking it for a few months along with 20mg adderall, 0.5mg Xanax, and 20mg propranolol. I started out taking 150mg wellbutrin... then upped it to 300mg a few months later... then still felt like something was wrong. I was extremely sluggish, I had no desire to do anything or go to the gym anymore, didn't matter how much sleep I got; I woke up feeling like garbage, I still had those "I want to be alone sitting emotionless in bed" feelings that wasn't triggered by anything. Talked to my Dr... so we upped to 450mg. I must add that I've been a vegetarian for 2.5 years. In the last year, my health seemed to be going downhill slowly (this was leading up to the increase dosage). I ignored it (in denial) but my fiance noticed and he thought it was me not getting enough nutrients. In the last six months I noticed when eating and/or after eating i had stomach pains (before and after upping dose).
The stomach pains gradually increased, then the headaches started coming (after upping dosage). I've never had side effects from medication before so we were 100% convinced it was my diet. The last 3 months have been pure hell. Im eating bigger meals, food prepping, etc. but the stomach aches never stopped. We started to think I could have an ulcer or something. Last month up until now, I wake up with headaches, some headaches are so severe I throw up, my stomach hurts constantly... im miserable. I finally had enough and searched my symptoms. I found that B12 is produced by animals and I can't get b12 from plants. So I ordered a vegan b12. My protein levels were probably low as well, so I bought vegan protein with 20g of protein and hemp protein with 15g. I have been taking those for the last 2 weeks and I feel "better" in terms of energy... but my stomach pains/headaches are still happening. My fiance asked about my meds and what I changed. The only 2 I changed was the propranolol and Wellbutrin. He found that i had a majority of the side effects coming from the Wellbutrin and that 450mg is way too much and normally people go to 300mg. How the heck would I know?! The Dr. Made it seem normal. I'm one of those "go with the flow" type people, but I'm cutting back to 300mg Wellbutrin starting tomorrow and paying more attention to the meds I'm taking and the changes that go along with them. This was probably the longest "no" in history.
lorram
13 Sep 2018
@Ecatfish can I ask what brand you use for your vegan protein, vegan b12 and hemp protein??? I have all those stay in bed sluggish I have given up any sense of real life feelings your describing. I had stomach surgery and struggle with not getting enough protein, and b12, and all other nutrients, vitamins etc. I am not a fan of protein shakes. And altho having so many options to buy different brands, I'd rather not continue trying brands that don't work, I friend ed u and tried to pm but not allowed I guess
Happy2bee
27 June 2017
I have been on 450mg for 10 plus years and have no problem with the dosage.
Christamarina
13 March 2017
I have been taking 450mg generic WelbutrinXL once a day since March 2015. My psychiatrist and I slowly increased my dose until we reached this dose, which continues to help me. I don't experience any side-effects whatsoever. My advice would be to try a higher dose to see if it's helpful. Hope this helps you. Take Care!
HeretohelpDD
13 March 2017
400 or 450 is a very safe dosage of Wellbutrin. Seizures are extremely rare with this drug, especially if you haven't hadn't them before. I've been taking 450 mil for years and it's helped me a lot. One word of advice, take the brand version if you can. The generic versions often react very differently with people (just google it to see what I mean). Look into getting your doctor to give you a "brand medically necessary" prescription to get insurance to cover it.
Vintage Rose
26 Feb 2017
I recently just upped my WellbutrinXL from 150 to 300mg. I read a tip to help with dizziness & upset stomach. I have used it & really did well with the increase. The tip was take the Motion Sickness Pill Bonnine. Said it was better than other types. It worked for me! Also suggested to use it when titrating down.
bethann31
10 May 2016
I thought I would go ahead and try the dose increase after talking to several pharmacists.
I wasn't having any issues taking the bigger dose until now.
My head feels very funny & swimmy (if that makes sense), sort of dizzy; I am extremely sleepy, and my stomach has been bothering me.
Anyone have any thoughts?
Tk97
21 Aug 2017
I have have taken 450mg of Wellbutrin Sr, but after a short time, mabe a month, it made me feel "wired" you just have to experiment with your dose untill you find what's right for you, sometimes300mg is correct for a few months, and sometimes 400 mg is right for me, I have been on it for about ,10years, I have found 400mg to be right for me most of the time as long as I am also taking a mild anxiety medication. Valium, seems to be the best for me in combination with Wellbutrin Sr. You will adjust to the med. Increase, it shouldn't take long, but it does have some unpleasant side effects at first, even though 99.9% of DR's won't admit that or tell you to expect it, for whatever reason. It's always best to look into things on your on from reliable sources.
Kciampi
4 April 2018
Hi I just wanted to add to my previous comment that I would never take all 3 doses at once and you should see about 200 mg 2x day totaling 400mg especially if the 450 is making you feel sick. The directions say take each dose 12 hours apart but I take mine 6-8 hours apart and it's perfect. The SR peaks about 4 hours after dose and if you wait the full 12 hours you can feel the change in mood, energy, and ability to think clearly will set in about 8 hours for me. I take 1 about 8:30am and 2nd around 3pm and it's great. I have no trouble sleeping at all which is why I can't take anything that makes me drowsy but if you do have trouble sleeping then definitely take your 2nd dose by 4 pm.
Also, I had panic attacks before I upped my dose but found out they were related to my birth control interacting with the wellbutrin so I quit the birth control and felt so much less stress. Pharmacist didn't believe there could be a drug interaction between them but I did my research and the one bad thing about wellbutrin is it has many drug interactions. I took a sulphur antibiotic for bladder infection that I'd taken in the past, but my tongue and gums swelled up! You should always check that yourself on this site in fact. Good luck!
Related topics
wellbutrin, wellbutrin sr, depression, anxiety, bupropion, major depressive disorder, dosage, doctor
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