Hello, I was wondering how many people have had increased fatigue instead of the typical revved up/anxious response to Wellbutrin? I am on a starting dose of 150mg and am feeling fatigued and lethargic with subdued irritability. Did anyone who had this unique response find that it went away with further use or did it continue past 6 or so weeks and you had to stop? I am worried I may have to stop but am giving it a go...
Hi, lili! In placebo-controlled clinical trials 19.8% of patients reported feelings of sedation/fatigue during initiation therapy and so is considered a *common* response.
I would guess that this, like most side effects, should resolve within just a few days to a week or two but do let your doctor know that your Wellbutrin is affecting you this way.
Best wishes and I hope all goes well for you.
When I was on WB I had the same side effects. I was fatigued with anxiety and irritable. After 2 months it still did not go away. I was a little less fatigued but the anxiety and being on edge did not go a way. I had to stop taking it.
If you can tolerate staying with it for 6+ weeks you will know if the side effects are going to lessen and or go away.
Hope it all works out for you.
I was on Wellbutrin for a short time. I did have what they call the " honeymoon phase" where I had increased energy for a few day, after that initial response it was down hill & had to stop. I've yet to find an antidepressant that works, and I've had the genetic testing which is supposed to tell the docs what is best for your body! Don't stop any meds quickly - keep in touch with your doc. I've yet to find one that I can even tolerate the side effects & being full time in college I'm just trying my best to get through the day mentally. Best of luck!
I did the 1st time I took 150mgs XL, lasted 3 or 4 days then nothing at 300mgs it made me feel sick to my stomach. Not good for me but it works great for most people
I recently began taking the ER formula 150mg, once a day. I just finished my second week, the first week, I didnt need extra sleep felt pretty energetic and good. Now 4 days in. Im so tired, I can't keep my eyes open. I'm literally nodding off! sleeping 12-16 hours a day, 4 days now. Luckily I'm not working, I wouldnt be able to function. Im hoping this will pass soon. I was searching for an answer myself, questioning this as a side effect. I have never heard this being a side effect before. While searching for an answer myself, I stumbled ascross this thread/website. Thank you!! Now i have a better understanding.
I was searching for the same answer & it lead me here. I felt miserable on this med - could sleep off & on all day & nite; yet not get "good rest". I could literally b talking to someone one minute & next thing I knew - I fell back asleep for @ least a cpl hrs! Was also vry irritable - everything seemed to set me off & if i had to deal with customer service; well let's just say they got an ear full! Haha. Also, it didn't help @ all w/ depression & made me so unmotivated. I was only on it for 19 days but I couldn't take it anymore & had to stop. This med is supposed to be 1 that the effects & side effects may be resolved in a wk or 2 but that wasn't my experience. I know it does take longer sometimes as well; but I just couldn't go on feeling that way & sleeping so much, etc.
I'm sure this is useful for many ppl but we are all different - so if this didn't work - don't hesitate to try something else. I know i feel like I have tried everything w/out much luck but I have hope that there is something out there that will work for me. I also had panic attacks on this - only a cpl - but still too many for me to keep giving it anymore of a chance. It took me hours to feel like I could get out of bed & function & it shouldn't be like that. Good luck to you & to all of us.
Hi everybody! I’m glad I was able to read all of your questions, responses, answers, and experiences. I just started taking the generic Wellbutrin 150 XL yesterday. It has definitely made me very sleepy! I wasn’t expecting that. However, my therapist (who is a fan of the drug) suggested I start taking it at night, before bed. I’m going to try that and see how it goes, because I, like you, can’t afford to be sleepy and drowsy all day. I’ll post an update when I get some results.
- Wellbutrin Information for Consumers
- Wellbutrin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Wellbutrin (detailed)
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