Vortioxetine - Anyone experience rage on Brintellix?

No I didn't.
I took Brintellix for two weeks, and this medicine only relaxed me and gave me much patience most of the time. No rage was experienced.
I stop taking Brintellix since it made me irritated at night when I went to sleep, and I was regularly needed sleeping pills for getting to sleep.
On the good side, Brintellix helped me allot with the depression, and gave me lots of daily motivation.

Know this is an old post, but wanted to contribute. I have been on Vortioxetine (5mg daily) for 2 months now, and I have *definitely* noticed that I have been feeling increasingly short tempered and irritable. It seems that everything and everyone gets on my nerves and I have no problem letting them know about it! I feel it has made me a really mean and unpleasant person. I experienced a similar thing whilst on mirtazapine, only then I got really angry, to the point of rage. I've also noticed a definite loss of empathy towards others. I feel awful for not being able to give my 10 yr old Daughter genuine affection. It's like I'm playing a role. I'm going through the motions, but I don't actually *feel* anything. I'm coming off it. It hasn't helped my depression in the slightest. Plus, it's not fair on my family and I don't like this version of me one bit!

I have been on Trintellix for 4 weeks. The first week I was suicidal. I cry constantly and I feel rage and anger all the time. Not a good drug at all!!!

I am on Trintellix for the first time I started on 5mg and I felt great I was doing things not just sitting on the couch feeling doomed and no longer crying I maybe got a little irritable but not much.
But my dr upped my dose to 10mg 7 days ago now and boy am I having a hard time Crazy dreams Sweating all night feeling exhausted all day from the crazy dreams and not sleeping and Mad at everything! I have such a short fuse I am freaking out! I left a message to my dr yesterday no response yet I have to get back to 5mg and hopefully also add something for my anger?

You Are Not Alone. I've been on this medication for approximately 4 weeks. Sometimes I feel completely out of control. Side effects are side effects you have to govern them by yourself and talk to your doctor.

Antidepressants can provoke episodes of hypomania/mania in some patients. Please consult your doctor for professional advice.

Yes, I have a rage increasing after 7th weeks. Now, I will go to my psych doctor. This case disturb me too much. Drug is perfect working but the side effect is very annoying. I was taking 10mg before but now decreased it to 5mg.

Yes! I too am experiencing significant irritability, impatience, etc. during my 2nd full week on 10 mg of Trintellix. I am also taking 10 mg of Lexapro, down from the 20 mg I was on pre-Trintellix. I LOVE Lexapro, and it was a wonder-drug at controlling my anxiety and ADD-related impatience/irritability. The only reason my doctor decided to start transitioning me to Trintellix is because of my significant weight gain (26 lbs in the 2.5 years I was on Lexapro.) Honestly, though, at this point I'd gladly gain 20 more pounds just to go back to feeling zen, calm and collected, as I did before! Anyone have any additional thoughts on any of this - I am eager for feedback!

I have been having rage and irritability on Trintellix (Brintellix). Also difficulty focusing and increased sweating. I had tapered off of Wellbutrin and Cipralex, which I had been on for a number of years, and titrated up on Trintellix from 5mg to 10mg. Although I have appreciated the increased energy and motivation of Trintellix, the rage/irritability is too much for me (and those around me, I'm sure) to deal with. I am back down to 5mg, and have a follow-up appt with my doc this week. I don't think I can continue with this med.

I have been on Trintellix (Brintellix) at 10 mg daily for 3 years. I have not had a reaction as described. My search of the literature found nothing. Individual reactions can be different so I can only suggest you talk to your doctor.

Also, is it possible these are anxiety/panic attacks? Trintellix has little to no impact on panic attacks. Relieving the chronic depression may allow them to be more evident. Just a thought.

–RonV2

Yes I have/do too. I've been on trintellix 20 mg for a few months now. I find I'm much less patient and easily frustrated, which is not me before starting these. Sometimes I laugh at myself because it is impulsive, sometimes I wonder why. I don't have an answer for you, but I thought I'd tell you I feel the same!