I have PTSD, depression and anxiety. I've been on Prozac for years and in March switched to Wellbutrin. I began having bad headaches, fuzzy thinking and just didn't feel right. I heard taking Prozac and Wellbutrin together can be more therapeutic together. Will taking Wellbutrin with Prozac possibly minimize the side effects I had just taking Wellbutrin?
Taking Wellbutrin and Prozac?
Question posted by k13collins on 9 Oct 2013
Last updated on 1 August 2021
I'd like to take everyone for their help.
Wellbutrin wasn’t good for me but works well for a friend of mine. If seems to me from what I have read it’s not a good fit if you have anxiety. I think it treats depression better but I have both and it made me feel worse the longer I took it. I am just on Prozac now and he added abilify. I think I like it pretty good.
I was taking the maximum dose of prozac and 450 mg of wellbutrin for awhile, it gave me severe tremors but it worked for a bit until the tremors were too much for me. I dont think taking wellbutrin and prozac together will dissipate your side effects. As soon as I went off prozac my tremors went away it was a relief. My antidepressant cocktail of choice is lexapro and wellbutrin together. Ive tried zoloft, effexor, cymbalta, and some of the bipolar medications. Im on 30 mg of lexapro which is above the therapeutic dose and 450 mg of wellbutrin which is maximum dose. The vyvanse (70 mg) really helped me with my depression.
Hi Kathleen. Do you still take either of these medicines? I am in Wellbutrin and I too feel foggy and have more anxiety with it. My contemplation is to either add or switch back to Prozac. Can you help me out on this? It’s so hard to make a decision. Especially when it takes so long for them to work. Ok have a trip planned in 2 weeks lol
I was prescribed r0 mg of prozac and 150 mg. Hcl Sr Wellbutrin . I have some serious,anxiety issue's so I also take 2mg of klonopin 3 times a day. I was still feeling depressed and very much in a dark and gloomy place. I went down to 20 my of prozac no better . I asked my doctor is I could take the Wellbutrin twice a day .. She said yes. I have been feeling more upbeat and not as gloomy I can definitely tell a difference in a positive way.
Today I am experiencing a little more anxiety and that feeling I always carry around being slightly down. I'm considering going back up to 40mg of prozac.
I have been fighting depression, generalized anxiety and social anxiety and recently mood disorder or a low level of bipolar for all my life . I can't say exactly how many year's I have been taking medication but I know it's at least 20.
It's a constant battle I fight everyday. I do believe I inherited mental illness from my mother and the way I was raised and my environment.
Looking back as very young child I was suffering from depression I just never new what it was until I was an adult.
I sometimes think especially after battling it this long I never developed the ability or emotion.. to be happy.
I often say I don't have the happy gene. It has ruled my life I have never a day I wasn't experiencing some degree of depression or anxiety.
Anyway sorry to go on and on..
Yes Wellbutrin and prozac can be taken together just make sure your doctor tells you the right dosage of each for you.
Another note all my drugs are generic and I don't know what brand if there is a difference of generic. I once would have told you it made a difference but after years of changing medications and combinations and name brand and generic I no longer think that's a factor in if they work for you or not .
Good luck and be sure to talk to your doctor.
I've been on Wellbutrin 450mg for years and it stopped working a while ago. My doctor has changed my meds (antidepressants and ADD) 6 times this year alone. I'm told I metabolize them too quickly for anything to work. I'm now trying 450mg Wellbutrin, 40mg Prozac and 90mg Adderall. I'm not finding any of it helps but at least I don't have horrible side effects. The only thing that worked for me was Wellbutrin and Lamotrigine. I had to go off it because of the side effects though.
I posted a response but u sure if you got it.
Thanks for any suggestions and or help
I taking 60 mg of Prozac I start Wellbutrin 150 I hope they are good together
I've been on Prozac 40mg for awhile now and now Dr put me on bupropuin/Wellbutrin and I feel good with it 175 mg but I can't handle the headaches, I don't know what to do
I too have taken Prozac for many years. I suffer from MDD, PTSD, anxiety, and Fibromyalgia (chronic pain). A year ago I was prescribed Wellbutrin XL 300mg and I had tapered off the Prozac for about six months.
I loved the fact that on Wellbutrin I could get out of bed and start to enjoy (tolerate) life again. However, I could not sleep and I became “more”anxious.
Since October 2017 I’ve combined the two antidepressants and feel better than I have in years!!
I’m not a doctor but I’ve been on at least six or more antidepressants in my life.
I have been taking Wellbutrin for 6 years for anxiety and depression. The first 2 weeks were awful, I had to take Xanax to keep the anxiety from becoming too bad. After 2 weeks of taking it I felt wonderful I was happy, outgoing, I lost 25 lbs, it was great! Then after a few years I was switched to the generic, not knowing there was a difference I took it for a couple years and felt nothing really, but I didn't have panic attacks so I settled. I recently went to a new doctor and he gave me a script for the brand name wellbutrin and he also started me on prozac based on my current depression.
I have been on both for 2 weeks and I feel emotional, forgetful, disorganized and lethargic. I'm not sure if it's just an adjustment period or if it will get better, but I feel awful.
If anyone else has taken Wellbutrin for a while and added prozac, please share your experience. Thank you!
Hi K13collins I would say yes it is very comman when you have several problems with anxiety that it takes more than one drug to balance use out and also they do many times use one to cover side effects of the other,Did your doctor tapper you off the prozac then go wellbutruin if not that could be one of the problems you don't just stop a ssri,prozac and start another unless it is a simular ssri medication.Ask you doctor as soon as you can there is no reason to have as many side effects with medications these days.Chuck Wise Pharmacy techniecian Cpht 35 YEARS retired.
I will tell you this, it absolutely depends on the generic brand of welbutrin that you take! Please, ask your pharmasist what brand you are on , and request different one before you give up.
Interactions between your selected drugs
bupropion ↔ fluoxetine
Applies to: Wellbutrin (bupropion), Prozac (fluoxetine)
Talk to your doctor before using buPROPion together with FLUoxetine. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. In addition, buPROPion can increase the blood levels of FLUoxetine, which may increase other side effects. You may be more likely to experience seizures with these medications if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should avoid or limit the use of alcohol during treatment.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Other drugs that your selected drugs interact with
Prozac (fluoxetine) interacts with more than 500 other drugs.
Wellbutrin (bupropion) interacts with more than 300 other drugs.
Interactions between your selected drugs and food
bupropion ↔ food
Applies to: Wellbutrin (bupropion)
Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. On the other hand, sudden withdrawal from alcohol following regular or chronic use can also increase your risk of seizures during treatment with buPROPion. If you are prone to frequent or excessive alcohol use, talk to your doctor before starting buPROPion. In general, you should avoid or limit the use of alcohol while being treated with buPROPion. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
I take Wellbutrin with my other antidepressant and have found them to be a great combo. Wellbutrin targets dopamine which the other antidepressants do not. Whether Prozac will eliminate side effects from the Wellbutrin I doubt. Usually these side effects go away after being on the med for a few weeks.
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