Can starting Pristiq make you feel easily aggravated?

Hi, Blessed!
Yes, these are side effects that commonly affect about 1-10% of users when first starting an antidepressant/anxiolytic. Fortunately, they generally resolve over just a few days to a week or two and usually lessen as the days go by.
"Psychiatric
Common (1% to 10%): Anxiety, irritability, nervousness"
If they are disrupting your life or persist longer than a couple of weeks let your doctor know but you should feel better quickly now.
Best regards,
Wildcat