Does spironolactone cause severe skin itch?

Yes. I had taken it for 1 week and developed the worst rash on my face. And my body was continuously itchy. I would never, ever take spironolactone again.

If your kidneys cant get rid of phosphate efficiently, the phosphate lodges in the skin and causes some maddening itchiness. (I realise that Spironolatone is supposed to preserve Potassium but it is really just light metals that seem to get preserved).

Yes it can cause hives, rash and itching. I have been taking it for nearly five years and only starting to itch in the past few months. But that has been after a number of allergic reactions to others medications so I can't say my itch is from the spironolactone.