Does Prilosec cause joint, bone and/or muscle pain?

Yes. I have taken it before and it made my ankles and feet swell. Then started again 2 weeks ago. Today I woke up to a swollen stiff and painful left knee which started inthe middle of the night, pain in my feet, ankles, both knees and hips. I will never take it again.

I am so glad I found this thread. I have been on 40 mg omeprazole for 6 weeks due to GERD. The past couple weeks I've been having hand and wrist pain such that I can't bench press or do other sporting activities. I was assuming this was just old age creeping up on me and was getting depressed but now I see a glimmer of hope that my pain could be caused by either this omeprazole or the red yeast rice I'm taking as a statin substitute. Great info here.

I started on generic Prilosec about six weeks ago and notice a lot of leg and sciatica like pain. I take Naproxen, and I was told by my doctor to take it to avoid getting an ulcer from side effects of Naproxen.

I took rabeprazole 4 years for acid reflux. Recently, my insurance co. said it wasn't covered any more so my doctor put me on omeprazole, 40 mg. This was Nov. 27 2018. Dec. 15 I woke up and could barely walk. The top of my right foot was swollen and hurting terribly. I had not injured it in any way. A few days later, the top of my right hand and one knuckle started to hurt so badly that I couldn't use my hand. I started to do research because I suspected it was my new medication. I stopped taking the omeprazole 4 days ago and the pain is slowly subsiding. I only hope there is no permanent damage. Also, during the time I was on this medicine, I was generally unwell. Sick all over, chills, not to mention I couldn't walk or use my right hand, and I am a very active person. I hope all of us heal soon from this horrible drug. Best wishes.

I was prescribed Prilosec and three days later I had pain in my buttocks and the back of my legs. I could not sit down. I first thought it must be siataca; purchased a special cushion to sit on; it didn’t help. It finally occurred to me-it’s the pills. Stopped immediately and it took three days for the pain to stop. I avoid or cut down on trigger foods. Horrible and dangerous pills.

I was dxed with EOE a few years back. Was given and Rx for Prilosec. After 2 or 3 months I was experiencing severe shoulder and wrist pain. Then while playing golf one day I tweaked my back which had never happened before. It stayed with me. Then when setting up a tent for my daughters soccer tournament (yeah, I am that kind of dad) a tendon running to my wrist ruptured. It should have hurt but I had been in so much pain I actually felt relief. I went on line and found that Prilosec has some serious side effects. So after I went off for about 6 weeks my joints stopped hurting. Ask your doctor about vitamin B12 and why it is important when prescribing Prilosec.

Yes it does! And it has also been linked to long term kidney damage.

I took Prilosec 20 mg. On the fourth day I began to notice hip pain increasing throughout the day. I awoke in the night with excruciating hip pain, absolutely equal in both hips. I had not changed anything except taking Prilosec. I checked online and found this site where a few others reported severe hip/back pain after taking this for only 4 days. I did not take it anymore and after a day the pain reduced gradually until it was completely gone. Haven’t had anything like that before or since. I started on Prevacid and have not had those side effects.

I started taking Prilosec for suspected GERD. On day 3 I noticed muscle/joint pain that got so bad it kept me awake all night. The aching in my legs and back was terrible. I also had elevated temperature. Never had these symptoms prior to taking.
So glad to hear I'm not alone! Going to switch to something else.

I was given a prescription for Prilosec (Omeprazole) 40 mg for possible duodenal ulcer. After reading possible side effects, I decided to try OTC 20 mg extended release tablet instead. Gastro pain improved from the 1st tablet so I was encouraged by the results. Four days into the treatment my legs are feeling weak with moderate muscle soreness. Today I woke up with excruciating hip and leg pain at 2 am. The pain is constant and making it hard for me to walk, relax or sleep. Called the company to see if this is a reported side effect. Naturally the company was not willing to discuss "other" patients reported side effects with me and merely wanted further information on my personal health, so not very helpful. Not sure of the reason for the hip and leg pain but I am stopping the medication immediately and reporting this effect to the prescribing nurse practitioner today.

My Dr. put me on Omeprazole 40 mg twice a day for a bleeding ulcer. Within just a couple of days I started having leg aches that within no time became unbearable. I could hardly walk. After 2 weeks in excruciating pain I googled and found out that the pain could be a side effect of the Omeprazole. I stopped that moment and a couple days later at my regular Dr appointment my Dr said it was a rare side effect but she agreed that I needed to come off of the Omeprazole. She said it happens to about 3-5% of people. She has switched me to something called Dexilant saying I shouldn't have the same problem. After reading about it, it also shows this could be a side effect. :( It's only been 2 days and I'm hopeful this pain will go away. It is honestly horrible and makes it hard to walk. I think what sucks worse is no one really believes it's as bad as it is.

I have used prilosec and the generic off and on every 3 to 6 months a couple weeks at a time the drug always worked well. Then I used it the past 2 weeks and develop severe hip and leg pain.can't even sleep hopefully pain will subside in few days .will never use this again.I changed to Apple cider vinegar before meals and small portions of food .acid reflux is under control try different things it can't hurt this drug might work for some people not me