I've noticed that when I started Praluent after a few months I started to get an increase in burning in my stomach. I went on a PPI but I had it still for months, despite making dietary changes. I reason it is the praluent because when I stopped it for a month I was starting to feel a lot better, then I gave myself a shot and 2 days later the symptoms returned bad again. I don't want to accuse the drug of being the cause if it isn't and I haven't seen any data or much reviews stating this. Symptoms range from burning, pain in the upper stomach, regurgitation and nausea.