I've noticed that when I started Praluent after a few months I started to get an increase in burning in my stomach. I went on a PPI but I had it still for months, despite making dietary changes. I reason it is the praluent because when I stopped it for a month I was starting to feel a lot better, then I gave myself a shot and 2 days later the symptoms returned bad again. I don't want to accuse the drug of being the cause if it isn't and I haven't seen any data or much reviews stating this. Symptoms range from burning, pain in the upper stomach, regurgitation and nausea.
Do PCSK9 inhibitors (Praluent or Repatha) cause GI issues?
Question posted by Clop80 on 22 Dec 2021
Last updated on 3 June 2022 by Westcreek
Answers
Westcreek
3 June 2022
I am not a Doctor but I am currently taking Repatha every two weeks. I've been on this for a year. At first no issues and after 3 doses I started getting constipation. Being on a Whole Food Plant Based diet I was a bit confused. Why am I having these issues. After 20 doses and the same day I had my second booster shot for COVID I had a lot of issues where it seems the muscle urge has left me completely. Called the pharmacist and was told to use Docusate and Senokot. No where in the literature on Repatha does it state that it will cause this. I went to an ER fearing bowel obstruction. They do CT scan and no partial or full obstruction. I have an Endoscopy set up for this month to check out the pain in my gut. I have been on Protonix 40mg (PPI) for 3 years (irritation from blood thinners). So hopefully my gut is okay, but either way I pray once I stop it that it hasn't caused too much damage.
malakeet
22 Dec 2021
No Issues with either drug. I'm sensitive to side effects and have IBS. Fortunately I've had no problems with either Praluent or Repatha.. I would look into other causes, especially since this is an injection and not taken orally. The first culprit I would look at is the PPI. I was on one of those in early 2000s and what you're describing is the exact issue I had with the PPI, although it was prescribed to me to stop the pain. GI issues are tricky to diagnose, but I seriously doubt if it's the Praluent. And the symptoms appear 2 DAYS after the injection??? Ummm no.
Clop80
22 Dec 2021
I appreciate the answer and I'll look into it. But food for thought, PCSK9 are not just located in your liver, they are also located in your the intestine, the kidney, and the central nervous system. So it can affect other organs. And Peak Plasma concentrations is 3-7 days after injection. Not a shocker that you can feel something so quickly. But I'll see if coming off PPIs help with this. Thanks.
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burning, stomach, praluent, repatha, pcsk9 inhibitors
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