Do PCSK9 inhibitors (Praluent or Repatha) cause GI issues?

I've been on Repatha now for 9 months and have developed the constipation issues also. I'm now cutting back on the Repatha to see if using it once a month vs twice a month with the 140mg dosage will stop the problem. Also, I've been starting to get pimple type outbreaks and a rash in my underarms and groin area. Hydrocortisone 1% takes care of that. I'll follow up on how my 1/2 dosage works and what it does to my cholesterol levels. Hope this helps anyone else.

I am not a Doctor but I am currently taking Repatha every two weeks. I've been on this for a year. At first no issues and after 3 doses I started getting constipation. Being on a Whole Food Plant Based diet I was a bit confused. Why am I having these issues. After 20 doses and the same day I had my second booster shot for COVID I had a lot of issues where it seems the muscle urge has left me completely. Called the pharmacist and was told to use Docusate and Senokot. No where in the literature on Repatha does it state that it will cause this. I went to an ER fearing bowel obstruction. They do CT scan and no partial or full obstruction. I have an Endoscopy set up for this month to check out the pain in my gut. I have been on Protonix 40mg (PPI) for 3 years (irritation from blood thinners). So hopefully my gut is okay, but either way I pray once I stop it that it hasn't caused too much damage.

No Issues with either drug. I'm sensitive to side effects and have IBS. Fortunately I've had no problems with either Praluent or Repatha.. I would look into other causes, especially since this is an injection and not taken orally. The first culprit I would look at is the PPI. I was on one of those in early 2000s and what you're describing is the exact issue I had with the PPI, although it was prescribed to me to stop the pain. GI issues are tricky to diagnose, but I seriously doubt if it's the Praluent. And the symptoms appear 2 DAYS after the injection??? Ummm no.