How long did it take to work?many thanks
Olanzapine - How long does it take olanzapine to work?Thanks?
Question posted by Lee1309 on 6 Aug 2025
Last updated on 13 August 2025
How long did it take on you're dose?
Added 7 Aug 2025:How long did it take on you're dose?
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Answers
Hi,
I was on Zyprexa brand name for Olanzapine for about 10 years, it may take a week in some people a bit more in others less to ease your symptoms, as everyone reacts differently to medications. What mental condition are you taking this 2nd generation atypical antipsychotic (this is the drug class it belongs to), if you don´t mind me asking?
At one point I took 30 mgs daily, I am bipolar 1 and was going through a rough patch.
I read you wrote down "anxiety", is that what you were prescribed this med for?.
The long drug class name it belongs to is because people are less likely to experience less possible side effects rather than using the older antipsychotics.
Info: https://www.drugs.com/olanzapine.html
Regards, masso
Hi masso atypical it's for PTSD /anxiety
Thanks
Hi Lee, why do you call me "masso atypical"?
I can help you, but I am a serious 56 y/o man been on meds for half my life. I do´nt brag, but my comment to you is that I take what I do here very seriously and I like to help people.
I take this as a 2nd job, because everytime I help someone I am helping myself, having said that, indeed we can have a laugh, etc., with my friends and you are not my friend... yet, up to you.
I mentioned I do´nt brag, but I have answered posts for almost 13 years in our community, there are levels here that the site administrators created in recognition of one´s commitment to help also active an non active members, there is only one more member who is my friend that is still active for about the same period of time.
If you want help I can provide it, if you want a laugh we can have a laugh but ,again, when it comes down to helping someone I am very serious.
You decide what you need/want, I am open minded as well, but the answer to your post was serious to me, I let you in one of my private episodes.
Regards, masso
Hi Lee,
"Off-label use of atypical antipsychotics in various settings increased rapidly after their introduction in the 1990s.
Use of atypical antipsychotics for the following off-label conditions has been documented in the scientific literature: attention-deficit hyperactivity disorder (ADHD), anxiety, dementia in elderly patients, depression, eating disorders, insomnia, obsessive compulsive disorder, personality disorder, post-traumatic stress disorder (PTSD), substance use disorders, and Tourette's syndrome.
Risperidone, quetiapine, and olanzapine are the most common atypicals prescribed for off-label use.
We found no reports describing off-label use of asenapine, iloperidone, and paliperidone.
According to a 2007 study, the use of atypical antipsychotics in the elderly is much higher in long-term care settings than in the community.
In 2004, nearly 25 percent of the elderly nursing home population received antipsychotics, with most receiving atypicals; males were more likely than females to receive them.
One year after the 2005 Food and Drug Administration (FDA) advisory warning, no state had actually changed its prior authorization policy in response to limit the use of atypicals in dementia. However, a more recent study concluded that the FDA advisory decreased the use of atypical antipsychotics in the U.S., especially among elderly dementia patients.
In 2003–2004, antipsychotics were prescribed in only 1 percent of overall mental health visits by children and adolescents, with most (99 percent) of these visits involving prescribing of atypicals.
Male children/adolescents were more likely than females to be prescribed atypical antipsychotics. Risperidone was the atypical most commonly prescribed to children.
At one large acute-care psychiatric hospital, quetiapine was used extensively for off-label conditions, and in a variety of off-label doses: only a quarter of patients had one of the diagnoses for which quetiapine is approved, and only a third received quetiapine in a standing dose regimen. Depression and substance-use disorders were found to be the most common associated diagnoses.
Atypicals are frequently prescribed to treat PTSD in the U.S. Department of Veterans Affairs (VA) health system."
SOURCE: National Library of Medicine/National Center for Biotechnology Information.
Hope this helps, masso
I wasn't being disrespectful masso meant I was on atypical tablets
Many thanks
Lee
I misread you're first comment
I'm sorry Masso no disrespect intended
I value you're help
Did it kick in slowly or was it a wake up and feel better
Thanks
Im struggling masso to find a relief from anxiety had a violent childhood the 6 years in the army
Hi, all clear, Lee.
Olanzapine may take some time to kick in from a couple of weeks( you will start to feel better) and up to 6 weeks to feel the full therapeutic effect of this med, you must be disciplined, it has to build up in your system, the initial dose you are on is important, the dr you have you need to trust 100% and he/she has to give you in return the same, 100% of their humanity and professionalism, I say this because a lived with my grandfather and he was a great human being and on top of that he was a dr, an emergency medicine specialist.
DO NOT take benzodiazepines: xanax (alprazolam), ativan(lorazepam), klonopin(clonazepam),valium (diazepam), those are the most common ones used for a quick fix, but they are a trap, they are very addicting and you want to avoid addiction at all cost, just don´t go down the fast lane.
Avoid the consumption of alcohol, alcohol is a depressant, many people say they can handle it and relaxes them, alcohol will make everything worse. I am a recovering alcoholic, been sober 100% for 23 years and it has made me a better person and I feel great don´t let the haters tell you " it´s cause you can´t handle it"... not true. I say this because booze intoxicates your brain and body, in the end you won´t succeed, stay clean also don´t go down the road of opioids, what I am tryinf to say is if you start with the right foot you will have to fight to stay above water but once you are there nothing will pull you under, being you your worst enemy in this stage you are in right now... desperation, you have to have complete control of yourself, if you need medications take them before you take any, research the drug the dr prescribed to you if you don´t agree look for a 2nd opinion, trial and error until you find your "cocktail" and also therapy helped me become what I am now, still I have many mental conditions that I learnt to control, but it is hard work, if I can so can you, again no pep talk but reality.
Keep yourself busy at all times, try power walks or running, reading, music , music is food for the soul, depending on what you listen, try relaxing music.
There are many meds out there that could do a better job for you, learn to rely on yourself, you do that with information, research gives you knowledge and that gives you the power after you have done it for some time, not to ask the questions but to answer them, anyone with the true commitment to oneself can do it, and at this stage a good medical professional.
I will leave some links from Drugs.com for you to read and analyze with your dr and an article on alcohol, and of course you can rely on me, I do not have all the answers, no one does and the ones that believe they do are the biggest fools of them all.
https://www.drugs.com/condition/anxiety.html
https://www.drugs.com/buspirone.html
https://www.drugs.com/condition/post-traumatic-stress-disorder.html
Ask your Dr about off label use of Quetiapine (same drug class as olanzapine) for anxiety, it helped me for my BPD 1 and alsomy anxiety, remember everyone reacts differently to medications.
Article on alcohol:
Alcohol alters your brain chemistry
Our brains rely on a delicate balance of chemicals and processes. Alcohol is a depressant, which means it can disrupt that balance, affecting our thoughts, feelings and actions – and sometimes our long-term mental health. This is partly down to ‘neurotransmitters’, chemicals that help to transmit signals from one nerve (or neuron) in the brain to another.
The relaxed feeling you can get when you have that first drink is due to the chemical changes alcohol has caused in your brain. For many of us, a drink can help us feel more confident and less anxious. That’s because it’s starting to depress the part of the brain we associate with inhibition.
But, as you drink more, more of the brain starts to be affected. It doesn’t matter what mood you’re in to start with, when high levels of alcohol are involved, instead of pleasurable effects increasing, it’s possible that a negative emotional response will take over. Alcohol can be linked to aggression you could become angry, aggressive, anxious or depressed.
Alcohol can actually increase anxiety and stress rather than reduce it
Unfortunately reaching for a drink won’t always have the effect you’re after.
While a glass of wine after a hard day might help you relax, in the long run it can contribute to feelings of depression and anxiety and make stress harder to deal with. This is because regular, heavy drinking interferes with neurotransmitters in our brains that are needed for good mental health.
When we drink, we narrow our perception of a situation and don’t always respond to all the cues around us. If we're prone to anxiety and notice something that could be interpreted as threatening in the environment, we'll hone in on that and miss the other less threatening or neutral information. For example, we might focus on our partner talking to someone we’re jealous of, rather than notice all the other people they’ve been chatting to that evening.
Alcohol depression = a vicious cycle
If you drink heavily and regularly you’re likely to develop some symptoms of depression. It’s that good old brain chemistry at work again. Regular drinking lowers the levels of serotonin in your brain – a chemical that helps to regulate your mood.
In Britain, people who experience anxiety or depression are twice as likely to be heavy or problem drinkers. For some people, the anxiety or depression came first and they’ve reached for alcohol to try to relieve it. For others, drinking came first, so it may be a root cause of their anxieties2.
Drinking heavily can also affect your relationships with your partner, family and friends. It can impact on your performance at work. These issues can also contribute to depression.
If you use drink to try and improve your mood or mask your depression, you may be starting a vicious cycle…
Warning signs that alcohol is affecting your mood include:
Poor sleep after drinking
Feeling tired because of a hangover
Low mood
Experiencing anxiety in situations where you would normally feel comfortable.
Hi Lee,
BTW, I got your messages when I turned on my cel and I answered as soon as I read them. I am not in the US, I was not making you beg. I´m not like that, so it was a misunderstanding and I gave it my all
I am sorry I did not answered sooner, I do feel bad, after all I am human... hope I helped.
Regards, masso
Many many thanks for the reply Masso I am tee total and I am not using street drugs just hope this works I'm at my limit at the moment and prey for relief
Many thanks
Thanks Masso I really appreciate your support
Don´t lose your faith, no need to thank me.
All the best, masso
Lee, try to find a support group for anxiety, it will help an I truly hope you find one where you are and give it a shot, it does help.
Stay safe, masso
Masso had a good day yesterday then I feel crap today only been on it 5 days is this normal ?
Many thanks
Lee
Yes Lee, happy you had a good day, it will be like this most likely one more week give or take, it means the medication is starting to build up in your system ... be patient, you´ll get there in no time.
Excersice helps, specially on your bad days, wear yourself out working out.
Regards, masso
Many thanks again Masso you are very reassuring
Lee, you need not thank me. I mentioned in a comment that you can rely on me, I want you to be happy and have a life, I can feel that´s what you are fighting for and it motivates me, you can count on me.
Excersice!!!
Just remembred, (getting old)... yoga and meditation helped me too, it may help you... give a shot.
Lee, yoga and meditation helped me, give it a try... if you are able to.
When you have depression or anxiety, exercise often seems like the last thing you want to do. But once you get started and keep going, exercise can make a big difference.
Exercise helps prevent and improve many health problems, including high blood pressure, diabetes and arthritis. Research on depression, anxiety and exercise shows that the mental health and physical benefits of exercise also can help mood get better and lessen anxiety.
The links between depression, anxiety and exercise aren't entirely clear. But working out and other forms of physical activity can ease symptoms of depression or anxiety and make you feel better. Exercise also may help keep depression and anxiety from coming back once you're feeling better.
Source: Mayo Clinic
All exercise can boost your mood by lowering levels of stress hormones, increasing the production of feel-good chemicals known as endorphins, and bringing more oxygenated blood to your brain. But yoga may have additional benefits. It can affect mood by elevating levels of a brain chemical called gamma-aminobutyric acid (GABA), which is associated with better mood and decreased anxiety.
Meditation also reduces activity in the limbic system — the part of the brain dedicated to emotions. As your emotional reactivity diminishes, you have a more tempered response when faced with stressful situations.
Drugs and talk therapy have traditionally been the go-to remedies for depression and anxiety. But complementary approaches such as yoga also help, and yoga stacks up well when compared with other complementary therapies.
A number of small studies have found that yoga can help with post-traumatic stress disorder (PTSD). It is not used by itself, but as an add-on treatment to help reduce intrusive memories and emotional arousal and to produce calmer, steadier breathing. Deep, slow breathing is associated with calmer states because it helps activate the parasympathetic nervous system.
Source: Harvard Medical School
Thanks for the input Masso thank you for the reply means a lot and gives me hope
Many thanks
Lee
Hi Lee, hope you better... keep on going and be strong... you are welcome!!!
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Further information
- Olanzapine uses and safety info
- Olanzapine prescribing info & package insert (for Health Professionals)
- Side effects of Olanzapine (detailed)
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