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What is the mechanism of action of Bupropion?

Answers

WildcatVet 1 Feb 2013

Hi, CdayCS!
Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine, and does not inhibit monoamine oxidase or the re-uptake of serotonin. While the mechanism of action of bupropion, as with other antidepressants, is unknown, it is presumed that this action is mediated by noradrenergic and/or dopaminergic mechanisms.

This was copied from FDA Prescribing Information. Best wishes,

Votes: +0
mmthomas11 18 May 2021

So it does not effect brain cells like venlafaxine? 29 days ago I stopped 35mg venlafaxine & was put on bupropion 150 mg, felt no help so DR increased to 300mg. Then WHAM severe vertigo and nausea. With that and every withdrawal symptom from venlafaxine,
I am practically disabled. I need a psychiatrist to help me instead of a primary care DR right?

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