I've been taking Bupropion XL for years. Due to recent changes in my insurance, I've had to switch pharmacies. My new pharmacist refilled my prescription with Bupropion HCL XL as opposed to the Bupropion XL I'm used to. Even the pills themselves look different. Has anybody had this happen and will they be safe to take?
Bupropion XL vs Bupropion HCL XL?
Question posted by muchbetternow on 18 Feb 2016
Last updated on 23 October 2020
Hi muchbetternow; at one-time people were having problems with some of the generic Wellbutrin xl or sr. But as far as active ingredients FDA REQUIRED THAT EACH BATCH OF BRAND NAME OR GENERIC HAS TO HAVE 3.5 TO 4% OF THE ACTIVE INGREDIENTS IN THIS CASE IT IS THE BUPROPION and no matter how they label this generic they both are Bupropion HCl XL ALL the hydrochloride is part of the binder which is a type of salt you don't have to worry about. But as I said the active ingredient in brand name or generic are both allowed 3.5 to 4 % per batch difference and the inactive ingredients there are no regulations like this because they are just to hold the medication together There is a lot of misinformation but this is just in the wording somewhere The bupropion says HCl XL YOU have nothing to worry about. Chuck Wise Sr. medically retired certified pharmacy Technician Cpht. Oregon.
You can read that some people can tell the difference between brand name and the different manufacturers of the same generic meds. In other words not all generics are equal. Some of it has to do with the additives and fillers they use in generic that may have an adverse affect to the user. The FDA from what I read can make a generic acceptable with 90% of the active ingredient.
I use Bupropion 75 mg HCL instant release. From what I understand the HCL=hydrochloride. You did not say who the manufacturer is.
I am not sure why they put the letters HCL on a XL generic??
You can ask your pharmacist what the difference is. You can also ask if they can order the same manufacturer that you had before.
I am hoping that one of the more knowledgeable members may give you more information and clarification. Let us know how it works out or what you find out. Hope it all works out for you.
- Bupropion uses and safety info
- Bupropion information for Healthcare Professionals (includes dosage details)
- Side effects of Bupropion (detailed)
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