If anyone has ever taken this medication some feedback would be great. I was just prescribed 5 mg for the first week followed by 10 mg after that. Is that strong enough? How many mg's is enough for my brain to react to it. Iam worried that that's too much of a tiny dose and it won't do anything. My state of mind is so bad I would like to be on the highest dose possible. Any side effects with this drug? Iam also taking zyprexa so hopefully this would be a good combo. Thanks in advance!
Hi there, I am in the same situation. I am on the second day of 10 mg dose, I also worry it is not high enough.
@emed27. I have been on 10mg for one week. I just came off of celexa because I was having a breakdown and it wasn't working. I haven't noticed any improvement yet but it seems to take longer than other meds I've tried. Crying daily and sadness has not decreased yet but I have no choice but to give it more time. God bless and I hope it works for you. Keep me posted Carolha1
i started taking trintellix just over 2 weeks ago - my mood has changed a bit and i'm not crying at all which is great. I'm still a little nauseous and tired but it has definitely gotten better from the first week. They recommend 6-8 weeks to fully see improvement.
I was on zoloft about a year ago but went off because of the weight gain - SSRIs do work! just need to be patient!
10 mg is the initial loading dose for Trintellix to avoid or minimize any potential side effects. Some improvement may be apparent in the first few weeks, but it usually takes 4~6 weeks to feel the full benefit and 6~8 weeks to achieve steady sate therapeutic blood levels.
Try to be patient when starting an antidepressant because they will work very effectively for almost everyone.
I am only on 5 mgs. and have literally "come out of the closet", which is where I was spending ALL my time since I could NOT face the world or even the daylight. I am nauseous and a bit lightheaded but the difference is quite honestly night and day. PLEASE just give it a chance.
I've been on 10mg of Brintellix for 9 days. I didn't experience any side effects at first and instantly felt my mood improve (probably just a placebo effect). But during the last three days I've felt awful (really low and helpless), have had a strange headache, and haven't been able to sleep although I am also taking something else to help with my sleep. Has anyone had a similar situation? Is it normal? I hope this medication starts to work soon.
I have been on Trintellix for 1 month. First week at 5 mg., past 3 weeks at 10 mg. I still feel nauseated at times, am constipated, have lots of eye issues and get brain "zings." I saw my dr yesterday and he wants me to continue at this dose and I am to meet with a a counselor once a week. I am having lots of ups and downs. Very stressful dreams also. I've suffered with depression for over 30 years. My dad was bi-polar and struggled all his life. I was taking Zoloft for many years before Trintellex and I am so hoping this helps. If you trust your dr., then I would continue with his med. plan. I know I just want to feel better. I'm sure you do too. Best of luck to you.
Hi! Im taking 20 mg Trintellix once a day in the morning. With this drug it seems common to start at 5, then 10, then 20 if needed, 2 weeks on each dosage. I dont think you can jump onto it at max dose, body needs to get used to it a bit at a time to see at which dose you can stay at. Besides the side effects could turn you off it if you start too strong. It's been a great drug for me having tried many others! I wish you luck and you feel better on it!!
Hi! I started 5mg trintellix about a month ago. I noticed slight improvement in my crying and depressing thoughts but increased to 10mg about 1-2 weeks ago and I have noticed much better improvement in both as well as overall mood improvement. My doctor told me it would take several weeks (6-8) to notice any improvement at all and I found that was well over my experience. I would say the 5mg improved within 2 weeks and then leveled slightly and the 10mg has been helping improve since about the first full week on it.
I'm sure it is different for everyone, and I'm almost POSITIVE I'm experiencing a placebo effect, but I feel so incredibly clear-headed on DAY 2 of this medicine (starting at 5mg). There's no way it's the medicine... right? Either way, I am not complaining.
I was on Effexor for 4 years with no real change (but too lazy/annoyed to get it fixed). I switched to Cymbalta for 5 months and felt completely terrible all the time. I was off medication completely for 2 weeks and felt reaaaally terrible. On Trintellix for 2 days and I'm feeling great?! I think I'm just too hopeful for a drug that actually works. Time will tell.
Two years on sertraline with zero benefit. Still had depressed days, gained weight, eventually the bad days were outweighing the good ones. Just wasn’t the right medicine for me.
Diagnosed at same time as Trintellix was prescribed (this week). Placebo effect for me is likely the relief that I know what’s been causing my thoughts/moods. I am on my fourth day on 5mg. Will bump up to 10mg in three days. The placebo effect has worn off and now I’m waiting for the medicine to take effect.
Has anyone used Clonazepam in the interim and if so, what was your experience?
I started July 19 and I’m just now seeing my mood lift and life feels exciting again .
I’m on 10 mg daily .
The paper on Trintellix states mood, sleep, and appetite can improve in weeks 1-2. Depression and major depressive disorder will take about 6-8 weeks for improvement. You taking an average dose which I also take (10mg) for only a week or two won't cure your entire mind yet. 20mg is the max dose and is worked up to if 10mg fails after say 6 weeks. Give your body time bc the higher doses too quickly can give side effects like anxiety, insomnia, diarrhea, nausea/vomiting, and others. This is why we take it slow. Don't worry, your correct unique dose will be revealed and may surprise you. Some people take just 5mg for over 2 years and love it.
My Pain Management Physician started me on 5th then bumped my dose to 10mg. & I have had no improvement in mood, sleep habits or depth of depression. And in the 6 weeks I have been taking this medication, I have lost 14 lbs. Not good.
- Trintellix Information for Consumers
- Trintellix Information for Healthcare Professionals (includes dosage details)
- Side Effects of Trintellix (detailed)
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