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How long does it take for Latuda to start working?

8 Answers

Karen2931 7 Nov 2019

I took my 3rd dose of latuda last night and already have noticed a change. I find that I am no longer thinking about death all day like before. I am waking up earlier and have a bit more energy than I've had in recent months. I have bipolar depression and have struggled for 20 years to find something that would help with the pain it caused both mentally and physically. This is the first time I have felt hopeful. I hope it continues to work and I feel even better.

Votes: +0
CommaLlama 28 Dec 2018

My psychiatrist and my therapist both told me it can take two weeks for Latuda to work itself through your body before you begin feeling any effects. I was put on 40mg for schizoaffective disorder. At the time I had taken myself off of Seroquel 200mg a week before, and it was still getting out of my system. I've been taking Latuda for a week and a half now, in the evenings after a meal. Taking it with a meal helps it metabolize; without any food on your stomach you will only metabolize about half of a dosage of Latuda.


Now that the Seroquel IS out of my system and I've been on Latuda for nine days, I'm noticing that the voices are getting quieter every day, which in itself helps my anxiety and insomnia. The only negative side effect I've experienced is physical restlessness, particularly in my legs and a bit in my arms, in the evenings shortly after taking the medication. I've seen this is a common side effect in a lot of people that the drug is otherwise helping. I tried drinking a cup of chamomile tea last night and it helped this issue ease off in about an hour and I was able to sleep uninterrupted for five hours.

It helps when starting any new medication(s) to keep a journal alongside it. Document anything new you notice, or whether you notice anything at all, on a day to day basis. Your notes don't have to be super organized; just jot down the date and write what you notice underneath it. It helps you see your progress during the adjustment period of the medication, and it also helps your doctor see if the medication will be a good fit for you.

Votes: +1
MeggieGirl 9 Oct 2018

I remember feeling an almost immediate response to Latuda. I'm talking a few days, and the cloud was lifted. Latuda made me the happiest person in the world. I had to stop it because of weight gain, despite it being a weight-neutral drug. No other bipolar drug has has the same effect, so I am going to ask to be placed back on Latuda again this week, and use smart strategies to watch my food intake.

Votes: +1
moreluvr 9 Oct 2018

I was prescribed Latuda Les than 24 hours ago for Bipolar 2 depression. I already feel so much better I can't believe it! Even the muscle tension is relieved. I don't feel medicated. Just feel good.

Votes: +0
WildcatVet 16 June 2018

"How Long Does It Take For Latuda To Work
May take 3 to 4 weeks at an appropriate dose for you to see effects and possibly 2 to 3 months to see full effects."

I started Latuda at 80mgs/day one week ago. Nothing yet... but no side effects either!

Votes: +0
APHRO369 16 June 2018

I took latuda last night and instantly feel different. HOWEVER... it did make me sleepy and I hadn't been sleeping or eating and I did both after taking it. That could play a part but I'm enjoying it either way.

Votes: +0
MJH2034 17 June 2017

I am on day 5 and still nothing feel the same maybe slightly worse.
On 20mg

Votes: +0
GuinnessGirl54 24 Aug 2014

It took one and a half weeks for me to feel anything. Some people find it works in two weeks and I've met people that it took three to four weeks to work for. Depends on your body. Hope it works quickly for you! :)

Votes: +1
Jamilashaheed 30 Jan 2017

I had the same question... I'm curious because I've only been on it and Depakote for 4 days and feel great!! I was on this combination before but I didn't realize it worked so quickly! free discount card

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bipolar disorder, latuda

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