For me personally, I've been started at 300 mg 3x day for nearly three months now. My psych dr I believe said that it helps with the Remeron I take at night but also helps with my EVERYDAY anxiety, which she plans to drop my klonopin dosage from currently 1mg 2x day , to .5mg 2x day but I really do not want my klonopin to get cut because it helps so much but to be completely honest, I'd rather be on something like XANAX 1 mg / 3x day as needed. But the NEUROTIN I truly do believe has helped me as an addition to all the meds I'm on but it takes time to really take effect (4-6 weeks) but if you're really wanting to get the best of the neurotin, do not go more then 12 hours in between any does, I dont know y that's such a big thing but my dr. Insisted upon it so I agreed. Hopefully, my rambling helped you out on some way. One negative about Neurotin, at least from my p.o.v. Is that a side effect is rolling of eyes, I notice also that when you take it on an empty stomach, I become very light headed and uncoordinated when I take my 45mg Remeron w/ 1mg Klonopin.