Hello, I've had lingering bone, joint and muscle pain starting 24 hours after my first reclast injection. My doc said it wasn't related but I don't believe it, and the Aclasta (reclast) hotline said it could happen (esp if you have fibromyalgia, which i do), though it was unusual. Has anyone else here had that? If so, how long did it last and how did you cope? I am now on daily Percocet and wondering how long I have to endure this. My injection was about 2 months ago. Thx! SMac
Lingering bone and joint pain after reclast?
Question posted by smack99 on 19 Aug 2010
Last updated on 31 August 2025
The information on this page reflects personal experiences shared by our community members. It is not reviewed for medical accuracy and should not replace professional medical advice.
23 Answers Page 2
Sandra1810
11 July 2017
I also had my 3rd reclast infusion for osteoporosis in my wrists about 5 months ago. I had no problems with the first two treatments but my bones hurt now all over my body. My hip bones began to hurt within a day or two of the treatment and has not stopped. Now my hip bones hurt so much it is painful to sit or stand or walk. My fingers, my shoulders and my ribs and legs all hurt. I too would like to know when and if it will wear off.
sara12345
26 April 2013
Plus the Prolia injection, besides causing extreme bone brusing, also caused me flaming skin pain, sores in my mouth, and very high levels of my Parathyroid which singularly destroys the bones and every organ in the body. It has been since Sept. 13, 2012 that I have had these problems. This medication was new on the market and had not been tested for long. WHAT a MISTAKE.
sara12345
26 April 2013
To all of you, I'm wondering if your pain ever went away? Thanks. Sara
suzy8
26 April 2013
finally no pain from the reclast but took 3 years and lots of different treatments to get my kidneys sorted out
sara12345
26 April 2013
Wow Suzy, that's a long time! Did the doctors think it was from your Reclast or did they brush you off? I hope that they recognized the connection. You can also report the side effect to the FDA which I'm about to do. They do listen if enough people report the same side effect which wasn't caught during the drug trials. I'm also thinking that getting the Prolia injection was one of the worst things that I've done in my life.
suzy8
27 May 2013
i came back to uk to be with my family in 2010 and after 3 bouts of kidney infections 3 months apart they put me on low dose antibiotics for while and said they would restart my bone medication again but here in uk they do not use the reclast felt it was a cause of all my problems as they started within 24hours of having reclast long time 3 years to get your body back to normal am now taking risedronate once a week and have never felt better they had to totally clear my system of reclast dont forget it is there in your system for one year and takes longer for all the effects to go away hope you all get listened to like my dr did over here thankfully
sara12345
27 May 2013
Suzy, That's good that your system cleared out--finally after so long. I hope that you are aware that Risedronate is in a group of medicines called bisphosphonates. Consumer Reports (a well known research organization)says, "We have long advised—and did so again recently—that Fosamax, Boniva, and other drugs in this class, known as bisphosphonates, offer only modest benefits in building bone and preventing fractures. And, they pose some risks: throat or chest pain, difficulty swallowing, and heartburn. More rare but serious and long-lasting adverse effects include abnormal heart rhythm (atrial fibrillation); incapacitating bone, joint, and muscle pain; and bone loss in the jaw (osteonecrosis)." Just to warn you before you may have another bad experience.
crystal4ever
28 July 2017
I would also like to know I had mine done on Wednesday I spent 2 days in bed every muscle in my body along with my bones hurt and my kidneys hurt I will never have this done again they should take it off the market
sara12345
26 April 2013
Reclast is in the same class as Fosamax, Boniva and other meds that are all part of the bisphosphonates class. From Consumer Reports, "We have long advised—and did so again recently—that Fosamax, Boniva, and other drugs in this class, known as bisphosphonates, offer only modest benefits in building bone and preventing fractures. And, they pose some risks: throat or chest pain, difficulty swallowing, and heartburn. More rare but serious and LONG-LASTING (emphasis added) adverse effects include abnormal heart rhythm (atrial fibrillation); incapacitating bone, joint, and muscle pain; and bone loss in the jaw (osteonecrosis)." A friend of mine had terrible pain from taking just 2 tablets of Fosamax (a week apart) for many months afterwards.
Also the FDA has also found that Fosamax patients (in the same class as Boniva) can develop severe bone, muscle and joint pains within days of starting the drug. For some people, this pain stops almost immediately after discontinuing it. For others, it is ONGOING. (emphasis added)".
And I have severe bruising of my bones for many months after getting a Prolia injection which is in a different class from the bisphosphonates, but is also for osteoporosis.
Bottom line, I now steadfastly refuse to take ANY medications to treat my osteoporosis.
tashfin
25 April 2013
pharmacist
iblauraann
29 Nov 2012
Hi, I have just joined this group and I am sorry that I didn't find it sooner. My infusion was in Sept. 2008 and I had horrific bone, joint and muscle pain. I developed a severe case of fibromyalgia from it and it has caused me to go straight into pneumonia when I have an asthma attack (lifelong asthmatic). I just recently went through 4 surgeries on my eyes for cataracts. I fond by searching the internet that breast cancer patients also developed cataracts when they were given zometa (Reclast). I have kept a journal and my doctor has found that I seem to have a relapse of the pain about every three months. The relapses used to last a couple of weeks, but the last one lasted a week. I have not had a relapse since Aug. 8th and hope that it is finally getting out of my system. My doctor treats the symptoms and I am on neurontin for fibromyalgia and that also to some extent, helps the pain. I hope this helps you. You can contact me any time if needed.
Niki Walker
10 May 2012
I had the same reaction after my first injection which lasted about 4 days... was on the bed for the 4 days... With the second aclasta injection my doctor infused voltaren ( anti inflam ) along with the aclasta and I had no joint or bone pain as a result.
suzy8
10 Nov 2011
i ma so sorry to hear ur reactions to reclast mine are even worse within 24hours i reacted very badly with the joint pain high temp chills pain so bad it made you cry so they gave me another medication for osteo and now every 3 months i come down with severe kidney infection the chills high temp and the severe pain that makes u cry i have decided to stop osteo medication and use calcium but have been told it could be a long time before i get back to normal i have been like this now for a year just over i wished i had never touched reclast i was fit until then never had kidney infections or pain like i get now
mc jackson
27 May 2013
Reclast infusion was the worse mistake of my life.bed ridden at times,taking a multitude of pain killers every four hours,this medicine was recomended to me by my docctor because of my age.wish I hadn't listened to him.I have now endured weeks of pain that I never had before.
bonepainyuk
20 Feb 2017
ihave been on Prolia for 3 years however my endo provider suggested I try reclast because prolia does not stay in the system. so I tried it. prior to the infusion I had a hep lock started but it infiltrated. on my right forehand. since then my right hand 3 fingers 345 have been swollen and tender topoint of not being able to bend or put rings on. the tenderness started 24 hours after the inection when I had total joint boy muscle pain, no fever or cough but achy all over. I went to the er the next day andmy calcium had dropped to low normal levels. the joint pain has subsided but 4 days post infusion that was given to me on a Friday am ( in my antecubital space without infiltration) I started having left jaw pain upper and lower side of moth with tenderness in my sinsues. saw endo dentist and no swelling of the area.
since that the tenderness in my jaw and sinuses has subsided along with the joint pain except for extreme fatique, I still have the right hand finger discomfort ansd swelling. no trauma except the infiltrated hep lock to m y right hand. I did not have any big side effects from the prolia and I certainly hope not to have this reclast infusion again - if ever. it is only once a year but I did not bargain for this at all. I am very concerned about the painful rom in my right hand since I am right handed and it makes it hard to grip, tyhpe or do anything right handed. my calcium and vitamin d levels will be monitored closely in one week and at one month.
Sclerodermapatient
6 March 2018
I’m a 50yo female. My Dr. prescribed Reclast for osteoporosis prevention; saying I should do this 1x a year. I tried asking several Drs. what to expect, etc. All I was told is I’d feel flu-like symptoms. I have to say I felt like I was on my deathbed. My entire body ached severely for days and I developed a bad cramp in my buttock/joint area to the point I was limping. It’s been over 2 weeks and I’m still fatigued and can’t seem to get out of this fog. I will never do this infusion again!
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aclasta, reclast, osteoarthritis, pain, muscle pain, injection
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