Will Lamictal make my Depo shot not work?

Interactions between your drugs
Moderate
medroxyPROGESTERone lamoTRIgine
Applies to: Depo-Provera (medroxyprogesterone), Lamictal (lamotrigine)

Talk to your doctor before using lamoTRIgine together with medroxyPROGESTERone. Combining these medications may reduce the blood levels and effects of lamoTRIgine. You may need a dose adjustment if you have been taking lamoTRIgine and are starting treatment with medroxyPROGESTERone. Similarly, if medroxyPROGESTERone is discontinued, your dosage of lamoTRIgine may need to be readjusted. Contact your doctor if your condition changes or you experience loss of seizure control during treatment with these medications. When medroxyPROGESTERone is stopped or interrupted briefly, be alert to potentially increased side effects of lamoTRIgine such as dizziness, drowsiness, nausea, vomiting, diarrhea, blurred vision, incoordination, tremor, restlessness, irritability, depression, anxiety, and mood or behavior changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

https://www.drugs.com/interactions-check.php?drug_list=1543-929,1430-848