I take 125 mg sertraline (zoloft) at nite because when at first prescribed, it made me very tired. That was theee years ago. After reading many zoloft threads, i guess i wanna know if its better to take the med in the morning ? At this point, my body has to be used to it so all i can really do is try, and if taken in the morning rather before bedtime, will it work more efficiently since its not being diluted by my sleeping most of it, off ?