I was offered Tramadol by my pain management doctor today. I am currently on Methadone for pain. I take 200 mgs. a day in divided doses. When checking the interaction between the two medications, there was a sentence I didn't understand. I was wondering if anyone could tell me (in laymans terms) what it means. It reads " Tramadol can also reinitiate physical dependence and precipitate withdrawal symptoms" Does that mean Tramadol will put me in withdrawal from my Methadone? I don't want to fill the script for Tramadol (50 mgs.) if that is the case. I have been on that dose of Methadone for about three years. Any help would be appreciated. Thanks so much. Fall Queen