I want to be safe, so can I take my hydrocodone in late evening? Without many side effects
Can I take hydrocodone while taking Zoloft? If so when?
Question posted by Teresawilliams on 12 June 2020
Last updated on 13 June 2020 by mackkath
I have been taking oxycodone, which I believe is the equivalent of hydrocodone, and have thus far had no side effect problems. I take one oxycodone at bedtime and it makes it easier to get some sleep. I don’t take Zoloft right now but I did take it several years ago and did not have a problem taking it with pain meds.
There is a moderate interaction between both meds, you can read the report by clicking on the link:
These are my thoughts, I am not a Dr.. Let us say you take zoloft early in the morning (it would help to know the dose of both meds) 9 am and you want to take the opiate, hydrocodone at 9pm, 12 hours have gone by, but zoloft has a half life of 26 hours and would be out of you system in 5 days give or take, depending on the dose the length of time,how long you have been on it, your metabolism, etc., so still if you wait those 12 hours there would still be sertraline in your system that could potentially interact with hydrocodone.
Now, I am just giving you my thoughts, because I believe opiates/opioids are serious business and I can not just sit here and not give you my opinion.
I am 51 and have been on meds since I was 19 or 20 and I try to be careful with potential interactions, plus I like to help other people.
Bottom line, try taking the AD early in the am and the hydrocodone not too late at night because you then have to take zoloft early in the morning... again.
Most likely you will be fine and nothing bad will happen to you, but narcotics as I mentioned are not to be taken lightly... nor any medication that can affect your brain chemistry... ones CNS.
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