To answer your question technically:
The single-dose pharmacokinetics of desvenlafaxine are linear and dose-proportional in a dose range of 100 to 600 mg/day. The mean terminal half-life, t1/2, is approximately 11 hours. With once-daily dosing, steady-state plasma concentrations are achieved within approximately 4-5 days. At steady-state, multiple-dose accumulation of desvenlafaxine is linear and predictable from the single-dose pharmacokinetic profile.
A drug's half-life is determined by finding out how long it takes a medication or drug to be eliminated from blood plasma by one half of its strength. So if you were on 50 mg Pristiq it would take approximately 66 hours to be completely eliminated from the blood.
Hope this helps,
- Pristiq Information for Consumers
- Pristiq Information for Healthcare Professionals (includes dosage details)
- Side Effects of Pristiq (detailed)
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