How long does Prednisone stay in you system after you quit taking it?
Question posted by Judith Leoffler on 18 Feb 2010
Last updated on 6 March 2019
This question has also been asked and answered here: How long does prednisone stay in your system?
The elimination half life of prednisone is around 3 to 4 hours. This is the time it takes for your body to reduce the plasma levels by half.
It usually takes around 5.5 half lives for a drug to be completely eliminated from your system.
With that in mind you could expect a dose or prednisone to be out of your system 16.5 to 22 hours later.
Other factors also need to be taken into account and include:
1. How much and how often you have taken the drug.
2. Your metabolic rate – a slower metabolism will increase the time a drug remains in your system.
3. Your age and health – older age and poor health will generally increase the time the drug stays in your system.
4. Body mass – generally the bigger you are the longer a drug will remain in your system.
Hope this is of help.
I’ve been off prednisone now for 3 days and feel like crap. No energy, feel like in a bubble, dizzy, tingling in arms and feet. Heart rhythm seems off. I was on meds for 10 days.
I had to be tapered off. I was on it for a year and half for serious kidney disease. Now off it but my arms still look awful. And still on azithioprine which caused a skin cancer (melanoma). Doesn't seem a problem with prednisone short term, but serious problems long term; but better than dying.
I have been taking Prednisone for my Ms and I have to say it works for me for a week or two just don't want my flare up to come back
I am having huge health problems after taking prednisone. My adrenal has not be right since. I am looking for a natural pathic dr now to help me. What are you all experiencing after taking this medication.
Yes I would like a direct answer to my question! I was prescribed 20 mg Prednisone, for bronchitis, x 10 day supply (I have asthma), I also worked as a pharmacy technician for 12 years. I left my job due to , health, issue.
the half life is roughly 4 hours. The prednisone should be tapered slowly and never stopped abruptly if you have been on it for over 2 weeks and were are a high dose. if you took it for 2-3 days you should be fine. The higher the dose and the longer you are on the drug the slower the taper. The drug itself should be out of your body less than 24 hours but flair ups can result if not tapered. Hope this helps.
- Prednisone uses and safety info
- Prednisone information for Healthcare Professionals (includes dosage details)
- Side effects of Prednisone (detailed)
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