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How long does Prednisone stay in you system after you quit taking it?

This question has also been asked and answered here: How long does prednisone stay in your system for... I have bronchitis?

Responses (6)

oktoday 18 Feb 2010

the half life is roughly 4 hours. The prednisone should be tapered slowly and never stopped abruptly if you have been on it for over 2 weeks and were are a high dose. if you took it for 2-3 days you should be fine. The higher the dose and the longer you are on the drug the slower the taper. The drug itself should be out of your body less than 24 hours but flair ups can result if not tapered. Hope this helps.

suzanne66 14 Jun 2011

The elimination half life of prednisone is around 3 to 4 hours. This is the time it takes for your body to reduce the plasma levels by half.
It usually takes around 5.5 half lives for a drug to be completely eliminated from your system.
With that in mind you could expect a dose or prednisone to be out of your system 16.5 to 22 hours later.
Other factors also need to be taken into account and include:
1. How much and how often you have taken the drug.
2. Your metabolic rate – a slower metabolism will increase the time a drug remains in your system.
3. Your age and health – older age and poor health will generally increase the time the drug stays in your system.
4. Body mass – generally the bigger you are the longer a drug will remain in your system.
Hope this is of help.


Jean freeman 6 Dec 2017

Yes I would like a direct answer to my question! I was prescribed 20 mg Prednisone, for bronchitis, x 10 day supply (I have asthma), I also worked as a pharmacy technician for 12 years. I left my job due to , health, issue.

Jim frank 9 Jan 2018

I am having huge health problems after taking prednisone. My adrenal has not be right since. I am looking for a natural pathic dr now to help me. What are you all experiencing after taking this medication.

Sunflower22 28 Jan 2018

Having many issues too. Never health issues now always sick, dizzy, anxious, cold and tired. In the middle of sorting it all out. Any progress for you? I was on 60 for 5 tapering. Had bad heart racing nervousness etc. Has been 30 days off and still not myself.

emferen 28 Jan 2018

I have just stopped taking this for an ear infection this week. Not for sure if this contributes but I have also experienced anxiety and depression to a different scary level.

Sheilcar2 18 Feb 2018

24 hours

blstites08 31 Mar 2018

I have been taking Prednisone for my Ms and I have to say it works for me for a week or two just don't want my flare up to come back free discount card

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