Hi, I got the Lupron Depot shot (11.25mg, 3-month) almost 3 weeks ago. So far I haven't seen any change with my symptoms or haven't experienced any hot flashes or anything. By the way, my endo is very mild, two spots close to my bladder, each less than 1cm. But it's very painful, and it hurts all the time, I think it's b/c of where it is. I am also taking add-back. So how long did it take for any of you before your pain started going away and you started getting the hot flashes? Any reply I would really appreciate! I am hoping to go back to work next week but I wanted to get an idea of how long it takes for this drug to work so that if needed i can take a few more weeks off. thanks!