I was prescribed just 25mg/day at bedtime. I wanted to discontinue it because I thought it was giving me weird side effects. I had been taking the medication for about 5 weeks when I chose to stop it.
It takes approximately 5.5 x elimination half life for a drug to be cleared from your system.
Amitriptyline is over 90% protein bound. Its elimination half-life varies from 10 to 50 hours, with an average of 15 hours.
If we use the maximum elimination half life of 50 hours it'll take 275 hours i.e. 11.45 days (5.5 x 50 hours). However there is always individual variation, so should only be used as a estimate.
For more information on Amitriptyline see:
I am writing for my 82 year old Aunt who has been battling BMS for over 10 years. About a year and a half ago, someone from another site suggested Noratrypline. She started to get some relief after about 2 mouth. She started out very slowly with 10mg and has slowly increased it to where she is now taking 50mg. Her doctor would like to increase it by 10mg additional but it is too strong for her (she has many medication sensitivies). THE ONLY THING that the Noratrypline has done for her, has taken the edge off the pain. This medication knocks her out, which is why it was prescribed to take it at night. Not a cure, but a slight help with the pain. Sorry I could not be more helpful, we have been to numerous doctors etc... Her Neice.
Hi. I have seen your question but it is dated 1 Feb 2010 and yet it has come up on my new email re BMS. Amitriptyline is the best answer for me at the moment, I have found nothing else which helps in the same way. The only sode efeect that I get is a dry mouth and when taking any drugs they take a while to get into and settle in our systems. Persevere longer if you can because it will help until something else is found. If this is dated Feb 2010 you hopefully have found some kind of solution, and if you have please let us know. Regards June
Does this medication give me a dirty U.A.
- Amitriptyline Information for Consumers
- Amitriptyline Information for Healthcare Professionals (includes dosage details)
- Side Effects of Amitriptyline (detailed)
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