My doctor and I have recently changed my antidepressant meds to include Prozac (30mgs), Welbutrin 150 mgs, and 1 deplin pill. I have been taking this combo for 3 weeks and all I notice is a voracious appetite which has resulted in a 6lb weight gain. This is an uncontrollable hunger feeling... almost all the time. I feel Deplin could be the culprit.
Has anyone experienced wolf hunger and weight gain while taking Deplin 7.5 mg daily?
Question posted by Lilyfrankie on 6 Feb 2010
Last updated on 22 November 2022
The information on this page reflects personal experiences shared by our community members. It is not reviewed for medical accuracy and should not replace professional medical advice.
6 Answers
Candiceg20
22 Nov 2022
I've been on Wellbutrin and Cymbalta for a few years now and recently added Deplin. I actually lost 20 pounds, until we started Deplin and then, BAM, 10LB weight gain. It's Deplin for sure. Nothing else changed for me except that.
WildcatVet
22 Nov 2022
Since there are no listed side effects for Deplin you should report your weight gain to your doctor so that they can document it for the Food & Drug Administration.
Inactive
11 Nov 2021
I have been experiencing an upsurge in hunger. I’ve also gained 5 lbs or more. I’m not taking other medication like the pp. I can’t afford to gain!
obaidharoon
15 Nov 2014
Prozac is the culprit this antidepressant gain weight a lot en fact it increases sweet craving as well. While Wellbutrin and deplin got to do nothing with the
weight.
ryan321
20 Jan 2013
Deplin isn't supposed to cause weight gain, but... I started it 6 months ago and have gained 13 pounds. Everyone's body is different...
CC51
26 June 2011
Yes. I've been taking deplin for 6 months now and just realized possibly deplin is the culprit for my insatiable appetite. I eat all day and then I eat until my stomach will hold no more. Formerly I would be satisfied after a reasonable meal. I am not a heavy person but do struggle with weight maintenance more than ever now. I do have numerous issues including chronic sinusitus, malt lymphoma, recurrent gastric ulcers, iron deficient anemia, MTHFR, and CVID.
suzanne66
15 Feb 2010
Interesting... a reported side effect of Deplin is a loss of appetite.
See: https://www.drugs.com/mtm/deplin.html
However changes in appetite and weight is a reported side-effect of Wellbutrin... this is more likely to be the culprit.
See: https://www.drugs.com/sfx/wellbutrin-side-effects.html
You may also find these patient comments interesting.
https://www.drugs.com/comments/l-methylfolate/deplin.html
Related topics
deplin, prozac, depression, weight loss (obesity/overweight), weight
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