... to know if Adderall XR (extended-release) has a different half-life or simply a longer period before the breakdown process begins. Is it processed by the liver or kidneys? Is it water soluble or fat soluble? Finally, is it known to have any serious reactions with types of drugs.. namely opioid intake inhibitors ( methadone, suboxone, subutex) and anti-depressants ( seroquel, lithium, paxil, lexapro.etc... )
Adderall XR remains in your system for more than 24 hours after you take it. The duration of effect is roughly 8-10 hours, but the drug remains in your system for 40 to 50 hours (half life is 8-10 hours, and drugs are out of your system after 5 half-lives).
Adderall is processed by the liver. It is not completely water soluble or fat soluble (it is somewhat fat soluble but not much).
Adderall does not have any adverse interactions with Opiates. It also is perfectly safe to take with anti-depressants. It is even safe to take with Wellbutrin (as long as you don't have a history of seizures).
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