Doxepin is a third generation TCA or tricyclic antidepressant. Common side effect of this drug class is weight gain which is accomplished in two different ways. Way one is prolonging metabolism and carb cravings. The second way (which is more common for third generation TCAs) is an increase in appetite due to its histamine blocking abilities. Can it cause you to gain weight? Yes. Will it? Maybe. Some people don't gain weight while others do. If you start to gain too much weight on it then ask your doctor to switch to something else.
I've been on Doxepin for about 4 months. 100mg then bumped up to 150mg before bed everyday and have gained 20-25lbs now. I've asked my doctor to lower the dose and am contemplating going off of it. I use it for chronic hives due to its antihistamine properties and it works well enough, not 100% so I want to find something better with less side effects.
- Doxepin Information for Consumers
- Doxepin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Doxepin (detailed)
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