Why does doxepin cause weight gain? Does it change your metabolism in any way?
Question posted by buffy911 on 7 Aug 2013
Last updated on 3 September 2021 by Alaskanancy
I have been taking 50mg of Doxepin over 30 years. I had hives brought on by cold. I had been through some very traumatic years. A doctor explained the hives were a stress reaction to the environment. Antihistamines didn’t fully work to control the hives and accompanying sleeplessness. Doxepin worked beautifully. My friends noticed a big difference in my attitude being calmer and happier. Years later I noticed weight gain. I was hungry all the time. I tried other medications but nothing worked as well. I had weight loss surgery to control my appetite and lose weight. I am now 68 and in good health.
I've been on 6mg as Silenor since February for sleep, haven't noticed any weight gain with the low dose
I have been taking 150 mg of doxepin for several years and have gained 50 pounds. One hour after taking the pill I start eating and eating more. I need to find something else.
I have been on Doxepin for 3 years and I have gained 30 pounds. I do not get hungry n I do not crave carbs. I hardly eat.
My dr gave it to me for insomnia but it didn't work. She then added extended release ambient to go along with the Doxepin
I still don't sleep. My next dr appointment I'm going to talk to my dr about taking me off the Doxepin
I've been on Doxepin for about 4 months. 100mg then bumped up to 150mg before bed everyday and have gained 20-25lbs now. I've asked my doctor to lower the dose and am contemplating going off of it. I use it for chronic hives due to its antihistamine properties and it works well enough, not 100% so I want to find something better with less side effects.
Doxepin is a third generation TCA or tricyclic antidepressant. Common side effect of this drug class is weight gain which is accomplished in two different ways. Way one is prolonging metabolism and carb cravings. The second way (which is more common for third generation TCAs) is an increase in appetite due to its histamine blocking abilities. Can it cause you to gain weight? Yes. Will it? Maybe. Some people don't gain weight while others do. If you start to gain too much weight on it then ask your doctor to switch to something else.
- Doxepin uses and safety info
- Doxepin information for Healthcare Professionals (includes dosage details)
- Side effects of Doxepin (detailed)
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