I know the side affects say weight loss and loss of appetite. But it seems to be working opposite for me. I can't seem to stop eating. I am always hungry and I wasn't like that before I started on the medication. I just worked hard to lose 40 lbs and getting heavy caused alot of my depression. Menopause kicked in and I went from a size 6 to a 16. Now I'm back to a size 8 and I just can't go back to being heavy again. I was prescribed the new generic version of this medicine. Help. Psyched are you out there? Also, anyone else out there that has gained weight with effexor xr?