It worked well for my depression in the past. I took 75mg of Effexor XR with no need of increase for years. Was increased to 150 mg a number of years ago. Then the generic venlafaxine. Increased to 200 mg a a few years ago. As of Jan this year couldn't take the XR form due to insurance. Other than depression and high blood pressure have been healthy until about 6 years ago. My health has been deteriorating. It's been one thing after the other. I have been diagnosed with so many disorders, diseases and conditions. Last year I became unable to work. There is now more info on venlafaxine. I think many of my issues may be related to the the long term use of venlafaxine. I would appreciate any help.