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Can I take ibuprohen 800 mg along with acetaminophen/cod #3?

3 Answers

Dr Dave DDS 16 Jan 2015

This is acceptable because Tylenol 3 (30g codeine/300mg acetaminophen) is metabolized in the Liver and ibuprofen/Advil/Motrin is detoxed by the kidneys. You'll probably have enough synergistic pain relief with combining with Tylenol 3 so 600mg ibuprofen should be sufficient enough to notice its additional anti-inflammatory effects. BTW 650-1000mg Tylenol is a normal to high dose range so 300mg a small dose anyway. Its the codeine (opioid) you should be more concerned about if you're combining it with excessive alcohol or other opioids. Codeine is ok to take with ibuprofen at their typical recommended dosages..

(1)Dr. Paul A. Moore, chair of dental anesthesiology at the University of Pittsburgh in Pennsylvania:


"Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, work by blocking the synthesis of prostaglandins, suppressing both inflammation and pain, the researchers note. In contrast, acetaminophen does not suppress inflammation and appears to suppress pain through multiple other mechanisms. Increasing doses of these drugs can increase their effectiveness only up to a point, and high doses can be toxic, but the 2 together can suppress pain better than either alone, the authors write."

*This is for informational purposes only it does not replace the advice of your personal medical professional.

Votes: +4
Imacomputa 8 July 2017

Thanks so much. Not only was this helpful it was informative.

midwestma 13 Aug 2010

Ibuprofen is an anti-inflammatory, or in the NSAID family, this is different from acetaminophen, so they can be taken together, without incident. They are two completely different medications. It may cause some stomach upset, so I would maybe have a few crackers or something on your tummy before taking this med. I have to do this with almost any med, just a word of advice. Always check it out, better always to be safe than sorry I wish you luck friend. Bless You

Votes: +3
Inactive 14 Aug 2010

You are very right

lizswan84 24 Oct 2012

oh my lord thank you so much! I was prescribed tylenol w/codeine and it was not helping with my swollen, inflamed throat at all!

arcanoidcyst16 13 Aug 2010

I would check it out on the INTERACTION CHECKER here on the site.That can tell you anything you want to know as far as combinding of medications.

Votes: +0 free discount card

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