Ive been net diagnosed as having mild depression, and was prescribed Wellbutrin SR 150 once a day (I got the generic version). It is now day 2 and I literally feel nothing. No negatives, no positives, just feel like I never took anything at all. I'm so frustrated because all I want is to feel normal. To wake up everyday with a zest for life. To have ENERGY! After reading all the reviews I was so excited about the possibilities; thought this was going to be my miracle. Am I just not allowing enough time?
Bupropion - How long to take effect?
Question posted by crysc1015 on 6 June 2015
Last updated on 1 September 2020 by Rbraband
Hello, here’s my experience so far:
I have been taking Wellbutrin for 2 weeks now. It was prescribed not only for my depression, but for my ADHD as well. If I was at 0% for depression and ADHD before, I’d say I’m currently at 30% for depression and 10% for ADHD. It doesn’t seem to energize and give a “euphoric” effect like my adderall did, but I am able to fall asleep faster. For the first few days of taking it I was EXTREMELY tired, but after a week that tired feeling has been subsiding. I take Wellbutrin SR 100 mg twice a day. I work late nights, so I wake up to take one early in the morning and go back to bed. Then I take another before work. I made the mistake of taking them 4 hours apart... DONT do that. It was an awful experience. Taking them 8 hours apart seems to be effective.
Sorry for the long reply (ADHD is not under control yet and my mind is all over the place). I hope this helps!
Wow - you are in the exact same boat as me! I just started taking with mild depression.. I am not super down, but I am just feeling neutral all the time. I have lost my excitement for life. I am also a vegetarian, do yoga.. I have a healthy life style, own a business, have a family.. but I just never feel happy or excited. Also very effected with Covid and my business being shut down - figured this is a good time to try out Wellbutrin (also the generic one) and see if it helps me be a better mom and wife and over all happier.
How are you feeling now that you are about 4 weeks into taking it?
How are you feeling
I’m so glad to be reading this! I’ve been taking it for 2 weeks, and I’m still getting angry and moody. I also have lack of patience and energy.
I used to take sertraline that worked within a week. But I hated the side effects.
Here’s hoping it does work.
I’ve been on Wellbutrin for just over two weeks and I don’t feel any better. I did have a temporary good feeling a few days in and it made me feel hopeful, but that went away. I have a more moderate depression that doesn’t necessarily leave me feeling sad much of the time, however, I’ve had a lack of motivation and zest for life for several years and knew it was time to do something about it. Since I’m not working due to COVID-19 and self isolating, I figured this would be a good time to gauge it’s effectiveness for me. So far, it’s not helping but I have no plans to give up since everything I’ve read says it takes 4-6 weeks. I’ve been in a real “rut” for several years, so I really hope this works because I don’t want to go on another medication that’ll cause sexual side effects or weight gain. Fingers crossed!
how are you with this medicine? And for anyone else I am on day 14. I am still depressed. On average would you think it takes longer than that? I have already tried lexapro and Prozac. After upping the Prozac I felt it was starting to work but I didn’t like the sexual side effects and that’s why I changed to Wellbutrin. And you know when you change you start all over again! Ugh. Just let good like advice on the timeline. I am so tired of feeling sad :(
You need time the same happened to me. It will get better
The first time I took it: 4-6 weeks before full effect
•More motivation to do things such as workout, go out with friends, talk to people, pursue hobbies.
•I felt less anxiety and felt a bit better. I had started taking it before a big break-up and at first I felt super depressed. After a three or so weeks, I felt much better.
•For me, it helped control my appetite. Before I was eating a lot and was overweight. After it took effect, I would feel fuller faster. I probably cut down half of what I was eating. With my motivation to workout, I was back at a healthy weight and maintaining it quite easily. It’s not something that happens with everybody though.
I lapsed and am taking it again now for smoking cessation. After two weeks, a bit of motivation has come back. I feel slightly less anxious. My mood is lifted a bit. It’s helping with my eating, but not quite there yet.
Basically I can see most of everything I felt before coming back. Hoping it will come back fully soon. I quit smoking on my own for over a week, but had an anxiety attack and smoked. Ruined my progress. Just after that week and a half I felt great. Almost like taking these meds. Hopefully the meds help me quit. The great feeling I had after quitting for that time mixed with the effects of the meds should make me feel super great. That’s my hope anyways.
I felt a feeling depression for the first two weeks, and now in week 5 I don’t feel much better.
I take Welbutrin and Zoloft. They work great for me. I agree with everyone else..it takes 4-6 weeks to really start working because it has to build up in your system. I see you posted this in June... how are you feeling now?
Thank you! Just Out of curiosity, what has each of your experiences with Wellbutrin been? In terms of what changed? What can I expect to feel?
It can take 2-4 weeks to feel better!!! Don't give up on this medicine it does work and it works great!!
Hello Crysc, Give it some more time. It can take up to 4-6 weeks to reach the full therapeutic benefit; however, you may start feeling better within 1-2 weeks. I started feeling better in about 10 days.. hang in there... pamee
Some people have a placebo effect and feel better at first. It takes 4-6 weeks for it to reach peak effect. I switched to it from a different one and the first few days I felt that kick. It doesn't stay until the pills are truly working.
Yes, you must give this medication time to work. It takes a week to build in your system and upwards of a month to become fully effective. So be patient and give it time. You'll be glad you did.
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