As most heart attacks occur in the AM, I have heard that taking metoprolol in the PM is better. You would have more medicine on board.
Does not make much difference, the only thing is that you take it at the same times everyday. The "er" in the name stands for extended release. So it will deliver a sustained amount of medication over a 24 hour time period. I take it twice a day at 8am and 8pm and when I took it once a day I took it in the morning. Hope this answers your question
A few years ago it was recommended that beta blockers including Metoprolol were best taken soon after waking up. This is because it counters the activation of the sympathetic nervous system upon awakening where the the risk of stroke, heart attack etc is higher compared to other periods of the day. Now though with development of special control delivery technology drug levels can be kept pretty constant over a 24 hour period so that as long as you take the beta blocker at the same time every day you should be covered.
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