I agree with kaismama with decreasing effexor while starting pristiq to alleviate side effects. The highest dose of effexor I have ever known was 375 mg. Certain patients, including more severely depressed patients, may respond more to higher doses, up to a maximum of 375 mg/day, generally in three divided doses so I guess its possible for the 450 mg or you meant to say 45 mg. Either way take the taper slow and easy as your Dr instructed. Good luck!
Pristiq was my miracle drug. I felt instantly better within a couple days of taking it (which was unusual in itself), my mood balanced, I even had surges of euphoria.
About seven months into taking it, I started to experience really really vivid bad disturbing violent nightmares. So bad that it started to affect my days. Couple that with growing muscle fatigue for no good reason, well, I felt I had to stop taking the drug. So, at only 50mgs a day, I stopped taking it. Really stupid move on my part. I should have weaned myself off. The nightmares stopped, but my regular prescribed sleeping pills stopped working. It was like my brain was light up with no way to shut it off. I doubled up on the sleeping pills, only to have it still not work -- so I wound up with no sleep and zombie feeling all the next day from the double dose, terrible.
I am on day five of no pristiq and am having horrific withdrawal symptoms. Suicidal feelings (my rational brain recognizes this as withdrawal symptoms, so I'm ok), crying at the drop of a hat, countered by horrific bouts of out-of-place rage. I have never had these kind of withdrawal symptoms with any other medication, and I have taken antidepressants for neatly 20 years.
I'm posting this because you going from 450 Effexor to 50 of Pristiq may seem like a good idea, but as others have advised, please be careful with this drug. I hope it provides the support you need and you don't experience the side effects I did, but be warned it's horrific to get off of it -- I have taken Effexor in the past, and didn't have anything like this when I stopped it.
I've been prescribed Pistiq for awhile now. I'm afraid to take it due to the side effects I've read about. 50mg.
Now my Dr wants to ability 2mg x a day. Which I've read the side effects are even worse.
So I'm sitting here in a great deal of pain & severe anxiety because I'm scared.
Any feedback on these meds would be greatly appreciated.
My pdoc said that 450mg Effexor = 225mg of Pristiq so I hope you are okay on 50mg of Pristiq when you have up to now required the equivalent of 225mg of Pristiq.
My pharmacist photocopied the section in her resource book. It says "Withdraw gradually to prevent withdrawal symptoms (particularly if higher dose or long term use); usually reduce dose by 25% per day; wait for 2-4 days before starting next antidepressant; consider hospitalisation during washout/changed over if severely depressed". I wonder though whether this is relevant when Pristiq is merely a Effexor already broken down? It might refer to swapping to a drug with a different chemical structure only.
My pdoc said merely to swap straight over (remembering to half the Effexor dose, to get the correct Pristiq dose).
Hope this helps - Sarnbarn, please let me know how you got on with your change over experience. Cheers :)
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