5-HTP - Is 5HTP and Citalopram compatable?
Question posted by William Sells on 13 Aug 2010
Last updated on 14 August 2010
Hello, the warning is major..meaning combining both of them is dangerous.
Interactions between your selected drugs
citalopram ↔ 5-hydroxytryptophan
Applies to: citalopram, 5-HTP (5-hydroxytryptophan)
GENERALLY AVOID: Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors and tryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.
MANAGEMENT: The concomitant use of serotonin reuptake inhibitors and tryptophan should be avoided.
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