ADVIL LIQUI-GEL 400MG CAPSULES

Active substance: IBUPROFEN

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PACKAGE LEAFLET: INFORMATION FOR THE USER
Advil Liquigel 400 mg Capsules
Contains ibuprofen
Please read all of this leaflet carefully because it contains important information for you.
This medicine is available without prescription, for you to treat a mild illness without a doctor’s help.
Nevertheless, you still need to use your medicine carefully to get the best results. Keep this leaflet, you
may need to read it again. Ask your pharmacist if you need more information or advice. You must see
a doctor if your symptoms worsen or do not improve after 10 days.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please
tell your doctor or pharmacist.
In this leaflet:
1.
What your medicine is and what it is used for
2.
Before you take your medicine
3.
How to take your medicine
4.
Possible side effects
5.
How to store your medicine
6.
Further information
1. WHAT YOUR MEDICINE IS AND WHAT IT IS USED FOR
Each liquid-filled capsule contains 400 mg of ibuprofen.
Ibuprofen belongs to a group of medicines called Non Steroidal Anti-inflammatory Drugs (NSAIDs)
that work by relieving pain and reducing inflammation, swelling and fever.
Your medicine is for the relief of mild to moderate pain including rheumatic and muscular pain,
backache, headache, dental pain, period pain, feverishness and the symptoms of colds and influenza.
Also for the relief of migraine (with or without aura symptoms e.g. vision disorders, numbness or
speech disorders) and the related symptoms such as feeling sick and sensitivity to light and sound.
2. BEFORE YOU TAKE YOUR MEDICINE
Please read the following information.
Do not give to children under 12 years of age, except on the advice of a doctor.
Do not take if you:

are suffering from or have had two or more separate occurrences of stomach ulcers or bleeding.

have suffered in the past from stomach bleeding or perforation because of treatment with this
medicine or any other NSAID.

suffer from other bleeding conditions or blood disease.

are allergic to ibup rofen or any of the other ingredients of this product, aspirin, or any other
NSAID painkiller.

suffer from severe liver, kidney or heart failure.

are in the last 3 months of pregnancy.
Tak e special care and talk to a pharmacist or your doctor if you are:

asthmatic or suffer from hayfever.

suffering from liver or kidney problems.

suffering from autoimmune diseases including Systemic Lupus Erythematosus (SLE) – a
condition of the immune system affecting connective tissue resulting in joint pain, skin changes
and disorders of other organs.

suffering from or have a history of gastro-intestinal disorders, such as ulcerative colitis or
Crohn’s Disease, because medicines such as ibuprofen may make these conditions worse.



in the first 6 months of pregnancy.

Medicines such as Advil Liqu ige l 400 mg Capsules may be associated with a small increased risk of
heart attack (“myocardial infarction”) or stroke. Any risk is more likely with high doses and prolonged
treatment. Do not exceed the recommended dose or duration of treatment (10 days).
If you have heart problems, previous stroke or think that you might be at risk of these conditions (for
example if you have high blood pressure, diabetes or high cholesterol or are a smoker) you should
discuss your treatment with your doctor or pharmacist.
Tak ing other medicines
Do not use this medicine if you are taking aspirin/acetylsalicylic acid with a daily dose above 75 mg,
or other NSAID painkillers.
Talk to your doctor or pharmacist if you are taking:

medicines that are anti-coagulants (reduce blood clotting, e.g aspirin, warfarin, ticlopidine),
diuretics (water tablets - increase the amount of urine you produce) or some medicines that
reduce high blood pressure (ACE-inhibitors such as captopril, beta-blockers such as atenolol, or
angiotensin-II receptor antagonists such as losartan), or other medicines, as these may affect or
be affected by treatment with ibuprofen.

other medicines such as corticosteroids (used in the management of asthma and to treat skin
diseases and other conditions), anti-platelet agents (generally used to thin the blood to help
prevent stroke or heart problems), cardiac glycosides (used in patients with heart problems),
selective serotonin reuptake inhibitors (SSRIs) or lithium (used to treat depression),
methotrexate (used in the treatment of some cancers, and to treat psoriasis or rheumatoid
arthritis), ciclos por in or tacrolimus (used in patients receiving organ transplants, and to treat
some skin disorders), zidovudine (used to treat HIV infection), quinoline antibiotics (a class of
antibiot ics used to treat some infections ), phenytoin (used in the treatment of epilepsy) or
antacids (used to treat indigestion).
You should always seek the advice of a doctor or pharmacist before you take ibuprofen with other
medicines.
Pregnancy and breast-feeding
Ibuprofen belongs to a group of medicines, NSAIDs, which may impair fertility in women. This effect
is reversible upon stopping the medicine. It is unlikely that ibuprofen, used occasionally, will affect
your chances of becoming pregnant, however tell your doctor before using this medicine if you have
problems becoming pregnant or are trying to become pregnant.
If you are in the first 6 months of pregnancy talk to your doctor before taking ibuprofen.
Do not take ibuprofen during the last 3 months of pregnancy,
Ibuprofen appears in breast milk in very low concentrations, but this is unlikely to adversely affect the
breast-fed infant
Important information about some of the ingredients of your medicine
If you have been told by your doctor that you have an intolerance to some sugars, consult your doctor
before taking this medicinal product as it contains sorbitol (E420).
Adv il Liqu igel 400 mg Capsules contain soya lecithin. If you are allergic to peanut or soya, do not use
this medicinal product.
3. HOW TO TAKE YOUR MEDICINE
This product is intended for short term use only. You should only take the lowest dose for the shortest
time necessary to relieve your symptoms. You should not take this medicine for longer than 10 days
unless your doctor tells you to. If symptoms persist or worsen consult your doctor.

Adults, the elderly and young persons over 12 years: 1 capsule up to 3 times a day as required. The
recommended interval between doses is approximately 6 to 8 hours, and you must leave at least 4
hours between doses. Do not take more than 3 capsules (1200 mg of ibuprofen) in any 24 hour period.
The capsules should be taken with water. Do not chew.
If you take more capsules than you should
If you take too many capsules, contact your doctor or hospital immediately. Bring the remaining
capsules with you to show the doctor.
4. POSSIBLE SIDE EFFECTS
Like all medicines, this medicine can cause side-effects, although not everybody gets them.
The following side effects are very rare (less than 1 in 10,000 people) but if you experience any of
these STOP taking this medicine immediately and contact your doctor or pharmacist:

Stomach ulceration or perforation. Symptoms could include severe abdominal pain, vomiting
blood (or liquid with what looks like coffee grounds), blood in the faeces (stools/motions) or
passing black tarry stools.

Inflammation of the brain lining (meningitis). Symptoms could include stiff neck, headache,
feeling or being sick, fever, or feeling disorientated.

Severe allergic reactions (could be life-threatering). Symptoms may include sudden signs of
allergy such as rash, itching or hives on the skin, fainting, low blood pressure, faster heart rate,
swelling of the face, tongue and throat, shortness of breath, wheezing or trouble breathing.

Asthma / worsening of asthma and other breathing difficulties.

Severe conditions of the skin that may affect the mouth and other parts of the body. This may
progress to a severe skin reaction which starts with painful red areas, then large blisters, and
ends up with peeling of layers of skin around the mouth, nose, eyes or genitals. This may be
accompanied by fever and chills, aching muscles and generally feeling unwell.

Liver problems. Symptoms could include yellowing of the skin or the whites of the eyes.
Medicines such as ibuprofen may be associated with a small increased risk of heart attack
(“myocardial infarction”) or stroke.
Other possible side effects
If any of the following side effects gets serious, or if you notice any side effects not listed in this
leaflet, please tell your doctor or pharmacist.
Less than 1 in 100 people may experience the following uncommon side effects:

Allergic reactions such as hives, skin rashes and itching (or Systemic Lupus Erythematosus SLE).

Abdominal pain, indigestion, heartburn and feeling sick.

Headache or dizziness.
Less than 1 in 1,000 people may experience the following rare side effects:

Diarrhoea, wind, constipation or being sick.
Less than 1 in 10,000 people may experience the following very rare side effects:

Reduction in blood cells, which can make the skin pale or yellow, cause fever, sore throat, mild
mouth ulcers, flu-like symptoms, exhaustion or weakness, easy bruising, or bleeding from the
skin or nose.

High blood pressure, heart failure or chest pain.

Nervousness, visual disturbance, ringing in the ears and dizziness.

Kidney problems. Symptoms could include swelling of the ankles.

Severe skin reactions. Symptoms could include blistering.



Blood in urine, or foamy appearance of urine.

Other very rare side effects with unknown frequency:

Worsening of symptoms of colitis and Crohn’s disease.
5. HOW TO STORE YOUR MEDICINE




Do not use this medicine after the expiry date shown on the end of the carton.
Do not store your medicine above 25°C.
Keep out of reach and sight of children.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to
dispose of medicines no longer required. These measures will help to protect the environment.
6. FURTHER INFORMATION
What your medicine contains
The active substance is ibuprofen.
The other ingredients are macrogol 600, potassium hydroxide, partially dehydrated sorbitol liquid,
gelatin, purified water, black ink (iron oxide black (E172), propylene glycol, polyvinyl acetate
phthalate, macrogol 400, ammonium hydroxide), phosal (lecithin, triglycerides (medium chain),
glyceryl stearate, oleic acid, ascorbyl palmitate).
What your medicine looks like and contents of the pack
Adv il Liqu igel 400 mg Capsules are oval, liquid-filled capsules printed on one side in black ink. The
blister packs contain 4, 6, 8, 10, 12, 16, 20, 24, 30, 32, 36, 48, 50, 60, 96 or 100 capsules. (Not all pack
sizes may be marketed.)
Who your medicine is made by
The Marketing Authorisation holder is:
Pfizer Consumer Healthcare Ltd, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom.
The manufacturer is: Wyeth Lederle SpA, Via Nettunense, 90 – 04011 Aprilia (LT), Italy.
This medicinal product is authorised in the Member States of the EEA under the following
names:
Ireland – Seclodin 400 mg Capsules
Netherlands – Advil Liquid Caps 400, Zachte capsules, 400mg
United Kingdom – Advil Liquigel 400 mg Capsules
This leaflet was last revised in: October 2011

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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