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Savella Side Effects

Generic Name: milnacipran

Note: This page contains side effects data for the generic drug milnacipran. It is possible that some of the dosage forms included below may not apply to the brand name Savella.

It is possible that some side effects of Savella may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to milnacipran: oral tablet

As well as its needed effects, milnacipran (the active ingredient contained in Savella) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking milnacipran, check with your doctor immediately:

More common
  • Blurred vision
  • body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • dizziness
  • ear congestion
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fear or nervousness
  • fever
  • headache
  • increased sweating
  • loss of voice
  • nasal congestion
  • pounding in the ears
  • runny nose
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • unusual tiredness or weakness
Less common
  • Back pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chills
  • decrease in frequency of urination
  • decrease in urine volume
  • difficult or painful urination
  • difficulty in passing urine (dribbling)
  • frequent urination
  • groin pain
  • muscle aches
  • pain or burning with urination
  • shakiness in the legs, arms, hands, or feet
  • swollen, tender prostate
  • tightness in the chest
Rare
  • Bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • bruise
  • discouragement
  • fall
  • feeling sad or empty
  • frequent urge to urinate
  • full or bloated feeling
  • heartburn
  • increased or decreased weight
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • lower back or side pain
  • pressure in the stomach
  • rapid weight gain
  • swelling of the abdominal or stomach area
  • tingling of the hands or feet
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • unusual weight gain or loss
  • vomiting
Incidence not known
  • Agitation
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • blood in the urine or stools
  • coma
  • confusion as to time, place, or person
  • convulsions
  • dark-colored urine
  • decreased urine output
  • diarrhea
  • difficulty with swallowing
  • general tiredness and weakness
  • high fever
  • holding false beliefs that cannot be changed by fact
  • increased sweating
  • increased thirst
  • itching
  • joint or muscle pain
  • light-colored stools
  • loss of balance control
  • loss of consciousness
  • mask-like face
  • muscle cramps or spasms
  • muscle pain or stiffness
  • overactive reflexes
  • pinpoint red spots on the skin
  • poor coordination
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • seizures
  • severe muscle stiffness
  • shuffling walk
  • slowed movements
  • slurred speech
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiffness of the arms and legs
  • sweating
  • swelling of the face, ankles, fingers, or lower legs
  • swollen glands
  • talking or acting with excitement you cannot control
  • tic-like (jerky) movements of the head, face, mouth, and neck
  • tiredness
  • trembling and shaking of the fingers and hands
  • twitching
  • unusual bleeding or bruising
  • unusual excitement, nervousness, or restlessness
  • unusually pale skin
  • upper right abdominal or stomach pain
  • weight gain
  • yellow eyes and skin

Some milnacipran side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Feeling of warmth
  • headache, severe and throbbing
  • redness of the face, neck, arms, and occasionally, upper chest
  • sudden sweating
Less common
  • Abdominal or stomach pain
  • change or problem with discharge of semen
  • decreased appetite
  • decreased interest in sexual intercourse
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • not able to ejaculate semen
  • rash
  • swelling of the testes
Rare
  • Acid or sour stomach
  • belching
  • bloated
  • change in taste
  • excess air or gas in the stomach or intestines
  • full feeling
  • heartburn
  • indigestion
  • irritability
  • loss of taste
  • night sweats
  • passing gas
  • sleepiness or unusual drowsiness
  • stomach discomfort, upset, or pain
Incidence not known
  • Swelling of the breasts or unusual milk production
  • unexpected or excess milk flow from the breasts

For Healthcare Professionals

Applies to milnacipran: oral tablet

General

The most commonly reported side effects were nausea, constipation, headache, dizziness, insomnia, and hot flush.[Ref]

Psychiatric

Very common (10% or more): Insomnia (12%)
Common (1% to 10%): Anxiety, depression, stress, irritability
Frequency not reported: Physical dependence
Postmarketing reports: Aggression, anger, delirium, hallucinations, homicidal ideation[Ref]

Nervous system

Very common (10% or more): Headache (19%), dizziness (11%)
Common (1% to 10%): Migraine, paresthesia, tremor, tension headache, hypoesthesia, somnolence, dysgeusia, convulsions (including grand mal), loss of consciousness, Parkinsonism
Frequency not reported: Serotonin syndrome[Ref]

Cardiovascular

Very common (10% or more): Hot flush (11%)
Common (1% to 10%): Palpitations, hypertension, increased heart rate, increased blood pressure, tachycardia, chest pain, chest discomfort, flushing
Postmarketing reports: Supraventricular tachycardia, hypertensive crisis[Ref]

Hepatic

Postmarketing reports: Hepatitis[Ref]

Metabolic

Common (1% to 10%): Decreased or increased weight, hypercholesterolemia
Postmarketing reports: Hyponatremia[Ref]

Hematologic

Postmarketing reports: Leukopenia, neutropenia, thrombocytopenia[Ref]

Genitourinary

Common (1% to 10%): Dysuria, ejaculation disorder, erectile dysfunction, ejaculation failure, decreased libido, prostatitis, scrotal pain, testicular pain, testicular swelling, urinary hesitation, urinary retention, urethral pain, decreased urine flow, cystitis, urinary tract infection[Ref]

Ocular

Common (1% to 10%): Blurred vision
Postmarketing reports: Accommodation disorder[Ref]

Gastrointestinal

Very common (10% or more): Nausea (35%), constipation (16%)
Common (1% to 10%): Vomiting, dry mouth, abdominal pain, decreased appetite, diarrhea, dyspepsia, gastroesophageal reflux disease, flatulence, abdominal distension
Postmarketing reports: Anorexia[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis, rash, pruritus, night sweats
Postmarketing reports: Erythema multiforme, Stevens Johnson syndrome[Ref]

Respiratory

Common (1% to 10%): Upper respiratory tract infection, dyspnea[Ref]

Other

Common (1% to 10%): Chills, pyrexia, peripheral edema, fatigue, contusion, fall[Ref]

Renal

Postmarketing reports: Acute renal failure[Ref]

Endocrine

Postmarketing reports: Hyperprolactinemia, galactorrhea[Ref]

Musculoskeletal

Postmarketing reports: Rhabdomyolysis[Ref]

References

1. "Product Information. Savella (milnacipran)." Forest Pharmaceuticals, St. Louis, MO.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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