Milnacipran use while Breastfeeding

Drugs containing Milnacipran: Savella

Milnacipran Levels and Effects while Breastfeeding

Summary of Use during Lactation

Milnacipran has not been studied in nursing mothers and the manufacturer recommends that nursing mothers not take milnacipran.[1] Because no information is available on the use of milnacipran during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Galactorrhea is reported by the manufacturer to be a side effect of milnacipran.[1] One woman who was being treated for depression took an intentional overdose of 950 mg of milnacipran orally. From day 5 to day 15 after the overdose, the patient noted a flow of milk from her left breast. The galactorrhea resolved without treatment.[2]

In a study of cases of hyperprolactinemia and its symptoms (e.g., gynecomastia) reported to a French pharmacovigilance center, milnacipran was not found to have an increased risk of causing hyperprolactinemia compared to other drugs.[3]

Alternate Drugs to Consider

Duloxetine, Pregabalin

References

1. Savella package insert. Forest Pharmaceuticals, Inc. January 2009.

2. de Haro L, Hayek-Lanthois M, Rodor F, Valli M . [Amenorrhea and galactorrhea after acute overdose with milnacipran]. Therapie. 2001;56:799-800. PMID: 11878113

3. Trenque T, Herlem E, Auriche P, Drame M. Serotonin reuptake inhibitors and hyperprolactinaemia: a case/non-case study in the French pharmacovigilance database. Drug Saf. 2011;34:1161-6. PMID: 22077504

Milnacipran Identification

Substance Name

Milnacipran

CAS Registry Number

92623-85-3

Drug Class

Adrenergic Uptake Inhibitors

Antidepressive Agents

Serotonin Uptake Inhibitors

Administrative Information

LactMed Record Number

703

Last Revision Date

20130907

Disclaimer

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Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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