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Rizatriptan Side Effects

In Summary

More frequently reported side effects include: dizziness, weakness, drowsiness, fatigue, paresthesia, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to rizatriptan: oral tablet, oral tablet disintegrating

As well as its needed effects, rizatriptan may cause unwanted side effects that require medical attention.

Severity: Major

If any of the following side effects occur while taking rizatriptan, check with your doctor immediately:

More common:
  • Chest pain
  • heaviness, tightness, or pressure in the chest and/or neck
  • pounding heartbeat
  • sensation of burning, warmth, heat, numbness, tightness, or tingling
  • shortness of breath
Less common:
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • increased heartbeat
  • irregular heartbeat
  • pain, tightness, or pressure in the neck, jaw, or throat
  • slow heartbeat

Severity: Minor

Some rizatriptan side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Dizziness
  • dry mouth
  • hot flashes
  • lack or loss of strength
  • nausea or vomiting
  • sleepiness or unusual drowsiness
  • unusual tiredness or weakness
Less common:
  • Agitation
  • anxiety
  • blurred vision
  • chills
  • confusion
  • constipation
  • depression
  • diarrhea
  • difficulty with swallowing
  • dry eyes
  • eye irritation
  • feeling of constant movement of self or surroundings
  • gas
  • headache
  • heartburn
  • heat sensitivity
  • inability to sleep
  • increased sweating
  • increased thirst
  • irritability
  • itching of the skin
  • muscle or joint stiffness, tightness, or rigidity
  • muscle pain or spasms
  • ringing or buzzing in the ears
  • sudden, large increase in the frequency or quantity of urine
  • trembling of the hands or feet
  • unusual feeling of well-being
  • warm or cold sensations

For Healthcare Professionals

Applies to rizatriptan: oral tablet, oral tablet disintegrating

General

The most commonly reported adverse reactions include pain/pressure sensation, asthenia/fatigue, somnolence, and dizziness.[Ref]

Cardiovascular

Common (1% to 10%): Palpitation, chest pain (tightness/pressure and/or heaviness), flushing
Uncommon (0.1% to 1%): Tachycardia, cold extremities, bradycardia, arrhythmia, ECG abnormalities
Rare (less than 0.1%): Syncope, edema/swelling
Frequency not reported: Acute myocardial infarction, blood pressure elevations
Postmarketing reports: Peripheral vascular ischemia[Ref]

Rarely, patients with and without a history of hypertension have experienced significant blood pressure elevations including hypertensive crisis with the use of triptans including this drug. Increases of approximately 2 to 3 mmHg have been observed in healthy subjects receiving 10 mg of this drug every 2 hours for 3 doses.[Ref]

Gastrointestinal

Common (1% to 10%): Dry mouth, nausea
Uncommon (0.1% to 1%): Vomiting, diarrhea, dyspepsia, tongue edema, abdominal distention, thirst
Frequency not reported: Ischemic colitis[Ref]

Nervous system

Very common (10% or more): Dizziness (14%)
Common (1% to 10%): Paresthesia, headache, somnolence, tremor
Uncommon (0.1% to 1%): Vertigo, confusion/disorientation, gait abnormality, memory impairment, abnormal coordination
Frequency not reported: Serotonin syndrome
Postmarketing reports: Seizure, dysgeusia[Ref]

Hypersensitivity

Postmarketing reports: Allergic conditions including anaphylaxis/anaphylactoid reaction, angioedema, wheezing, and toxic epidermal necrolysis[Ref]

Other

Common (1% to 10%): Asthenia/fatigue, neck/throat/jaw pain/tightness/pressure, warm sensation
Uncommon (0.1% to 1%): Tinnitus
Rare (less than 0.1%): Hypoacusis[Ref]

Dermatologic

Uncommon (0.1% to 1%): Facial edema, sweating, pruritus, rash, urticaria
Rare (less than 0.1%): Erythema
Frequency not reported: Toxic epidermal necrolysis[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Muscle weakness, stiffness, myalgia, muscle cramp/spasm
Postmarketing reports: Facial pain[Ref]

Ocular

Uncommon (0.1% to 1%): Blurred vision
Rare (less than 0.1%): Eye swelling[Ref]

Psychiatric

Common (1% to 10%): Euphoria, insomnia
Uncommon (0.1% to 1%): Agitation, hallucination[Ref]

Respiratory

Common (1% to 10%): Dyspnea
Uncommon (0.1% to 1%): Pharyngeal edema[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Maxalt (rizatriptan)." Merck & Co, Inc, West Point, PA.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of rizatriptan may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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